Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis. - Wikidata - awgldk - TriplyDB

Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis.

Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis.

http://www.wikidata.org/entity/Q36699754

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A phase II study of dacetuzumab (SGN-40) in patients with relapsed diffuse large B-cell lymphoma (DLBCL) and correlative analyses of patient-specific factors.Myc suppression of Nfkb2 accelerates lymphomagenesis.Germinal center B cell development has distinctly regulated stages completed by disengagement from T cell help c-Myc dysregulation is a co-transforming event for nuclear factor-κB activated B cells.Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies.The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.NF-κB directly mediates epigenetic deregulation of common microRNAs in Epstein-Barr virus-mediated transformation of B-cells and in lymphomas.Humanized c-Myc mouse Aberrant CD40-induced NF-κB activation in human lupus B lymphocytes Suppression of the LMP2A target gene, EGR-1, protects Hodgkin's lymphoma cells from entry to the EBV lytic cycle.LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation EBV LMP1, a viral mimic of CD40, activates dendritic cells and functions as a molecular adjuvant when incorporated into an HIV vaccine.Icaritin induces lytic cytotoxicity in extranodal NK/T-cell lymphoma.Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia.LKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation.CD40 ligand induces RIP1-dependent, necroptosis-like cell death in low-grade serous but not serous borderline ovarian tumor cells.CD40-signalling abrogates induction of RORγt+ Treg cells by intestinal CD103+ DCs and causes fatal colitis Constitutive CD40L expression on B cells prematurely terminates germinal center response and leads to augmented plasma cell production in T cell areas TFH cells progressively differentiate to regulate the germinal center response.Splenectomy with chemotherapy vs surgery alone as initial treatment for splenic marginal zone lymphoma NF-κB as a target for oncogenic viruses.TRAF5 is a critical mediator of in vitro signals and in vivo functions of LMP1, the viral oncogenic mimic of CD40.A functional TNFRSF5 polymorphism and risk of non-Hodgkin lymphoma, a pooled analysis Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas.The challenge of the microenvironment in B-cell lymphomas.The role of CD40/CD40L and interferon regulatory factor 4 in Hodgkin lymphoma microenvironment.Epstein-Barr virus-associated diffuse large B-cell lymphoma: diagnosis, difficulties and therapeutic options.Constitutive activation of alternative nuclear factor kappa B pathway in canine diffuse large B-cell lymphoma contributes to tumor cell survival and is a target of new adjuvant therapies.Cancer immunotherapy: activating innate and adaptive immunity through CD40 agonists.Bezafibrate and medroxyprogesterone acetate target resting and CD40L-stimulated primary marginal zone lymphoma and show promise in indolent B-cell non-Hodgkin lymphomas.Targeting high-grade B cell lymphoma with CD19-specific T cells.Exosomal sorting of the viral oncoprotein LMP1 is restrained by TRAF2 association at signalling endosomes.CD40 pathway activation status predicts response to CD40 therapy in diffuse large B cell lymphoma.Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence.CD40 ligand is necessary and sufficient to support primary diffuse large B-cell lymphoma cells in culture: a tool for in vitro preclinical studies with primary B-cell malignancies To respond or not to respond to CD40 agonism: That is the prediction.Regulation of B cell differentiation by the ubiquitin-binding protein TAX1BP1 Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model.Inducible expression of hyperactive Syk in B cells activates Blimp-1-dependent terminal differentiation.CD40L mediated alternative NFκB-signaling induces resistance to BCR-inhibitors in patients with mantle cell lymphoma.

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Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis.

http://www.wikidata.org/entity/Q36699754

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Caroline Hojer

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Cornelia Hömig-Hölzel

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Julia Rastelli

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Lothar J Strobl

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Stefano Casola

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Ursula Zimber-Strobl

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P2860

Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling

Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure

Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers

Targeted oncogene activation by site-specific recombination in transgenic mice

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

A fourth IkappaB protein within the NF-kappaB signaling module

Generalized lacZ expression with the ROSA26 Cre reporter strain

CD40-CD40 ligand

MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

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1317-1329

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6

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205

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Leticia Quintanilla-Martinez

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5360967

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2413030

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