Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1.
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Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cellsSelective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonismOpposing effects of protein kinase C and protein kinase A on metabotropic glutamate receptor signaling: selective desensitization of the inositol trisphosphate/Ca2+ pathway by phosphorylation of the receptor-G protein-coupling domainA role for Seven in Absentia Homolog (Siah1a) in metabotropic glutamate receptor signalingStructural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptorsBAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activityMetabotropic glutamate receptors: from the workbench to the bedside.Heptahelical receptor signaling: beyond the G protein paradigm.The metabotropic glutamate receptor subtype 5 mediates sensitivity to the sedative properties of ethanol.The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptorMitochondrial reactive oxygen species are activated by mGluR5 through IP3 and activate ERK and PKA to increase excitability of amygdala neurons and pain behavior.Parasagittally aligned, mGluR1-dependent patches are evoked at long latencies by parallel fiber stimulation in the mouse cerebellar cortex in vivo.Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.Therapeutic potential of mGluR5 targeting in Alzheimer's diseaseDifferences in agonist and antagonist activities for two indices of metabotropic glutamate receptor-stimulated phosphoinositide turnover.Pharmacological characterization of metabotropic glutamate receptors potentiating NMDA responses in mouse cortical wedge preparations.The PDZ scaffold NHERF-2 interacts with mGluR5 and regulates receptor activity.Translational Concepts of mGluR5 in Synaptic Diseases of the BrainNeurodevelopmental Expression Profile of Dimeric and Monomeric Group 1 mGluRs: Relevance to Schizophrenia Pathogenesis and Treatment.Effects of subtype-selective group I mGluR antagonists on synchronous activity induced by 4-aminopyridine/CGP 55845 in adult guinea pig hippocampal slices.Metabotropic glutamate receptors: physiology, pharmacology, and disease.Metabotropic glutamate receptor subtype 5 antagonism in learning and memory.Progress toward advanced understanding of metabotropic glutamate receptors: structure, signaling and therapeutic indicationsMetabotropic glutamate receptor subtype 5: molecular pharmacology, allosteric modulation and stimulus biasGlutamate triggers elevation of intracellular Ca(2+) concentration in neural precursor cells.Constitutive activity modulation of human metabotropic glutamate 5a receptors in HEK293 cells: a role for key amino-terminal cysteine residues.Depolarization-induced slow current in cerebellar Purkinje cells does not require metabotropic glutamate receptor 1.Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.Effects of varying the expression level of recombinant human mGlu1alpha receptors on the pharmacological properties of agonists and antagonists.Synapses between parallel fibres and stellate cells express long-term changes in synaptic efficacy in rat cerebellum.Requirement of rapid Ca2+ entry and synaptic activation of metabotropic glutamate receptors for the induction of long-term depression in adult rat hippocampus.Direct coupling of detergent purified human mGlu5 receptor to the heterotrimeric G proteins Gq and Gs.
P2860
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P2860
Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Molecular, functional, and pha ...... iants: comparison with mGluR1.
@ast
Molecular, functional, and pha ...... iants: comparison with mGluR1.
@en
type
label
Molecular, functional, and pha ...... iants: comparison with mGluR1.
@ast
Molecular, functional, and pha ...... iants: comparison with mGluR1.
@en
prefLabel
Molecular, functional, and pha ...... iants: comparison with mGluR1.
@ast
Molecular, functional, and pha ...... iants: comparison with mGluR1.
@en
P2093
P1476
Molecular, functional, and pha ...... iants: comparison with mGluR1.
@en
P2093
P304
P356
10.1523/JNEUROSCI.15-05-03970.1995
P407
P433
P577
1995-05-01T00:00:00Z