The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics.
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P1343
Is There a Space-Based Technology Solution to Problems with Preclinical Drug Toxicity Testing?Experimental models of hepatotoxicity related to acute liver failureState-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiologyKey Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation PlansAssessment of long-term effects of nanoparticles in a microcarrier cell culture systemA cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophenComparison of human hepatoma HepaRG cells with human and rat hepatocytes in uptake transport assays in order to predict a risk of drug induced hepatotoxicityComparative proteomics reveals novel components at the plasma membrane of differentiated HepaRG cells and different distribution in hepatocyte- and biliary-like cellsUp-regulating CYP3A4 expression in C3A cells by transfection with a novel chimeric regulator of hPXR-p53-ADStem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injuryApplication of the TGx-28.65 transcriptomic biomarker to classify genotoxic and non-genotoxic chemicals in human TK6 cells in the presence of rat liver S9Hepatitis B Virus Immunopathology, Model Systems, and Current TherapiesStrategies and Methodologies for Developing Microbial Detoxification Systems to Mitigate MycotoxinsMethod for finding metabolic properties based on the general growth law. Liver examples. A general framework for biological modeling.A comparison of whole genome gene expression profiles of HepaRG cells and HepG2 cells to primary human hepatocytes and human liver tissues.High Content Imaging and Analysis Enable Quantitative In Situ Assessment of CYP3A4 Using Cryopreserved Differentiated HepaRG Cells.The Chinese herbal medicine Sophora flavescens activates pregnane X receptorHepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicityFrom whole body to cellular models of hepatic triglyceride metabolism: man has got to know his limitationsRapid fabricating technique for multi-layered human hepatic cell sheets by forceful contraction of the fibroblast monolayer.The role of CYP3A4 mRNA transcript with shortened 3'-untranslated region in hepatocyte differentiation, liver development, and response to drug induction.Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins.Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation.A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicityAldolase B inhibits metastasis through Ten-Eleven Translocation 1 and serves as a prognostic biomarker in hepatocellular carcinomaComparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication.Organotypic liver culture models: meeting current challenges in toxicity testing.Development of a DsRed-expressing HepaRG cell line for real-time monitoring of hepatocyte-like cell differentiation by fluorescence imaging, with application in screening of novel geometric microstructured cell growth substrates.Combination treatment with 6-mercaptopurine and allopurinol in HepG2 and HEK293 cells - Effects on gene expression levels and thiopurine metabolism.GENE EXPRESSION PROFILING OF HUMAN LIVER CARCINOMA (HepG2) CELLS EXPOSED TO THE MARINE TOXIN OKADAIC ACID.Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen HepatotoxicityBile Acid-Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human HepatocytesModels of drug-induced liver injury for evaluation of phytotherapeutics and other natural products.Hepatocyte polarityIn vitro-in vivo extrapolation of hepatic clearance: biological tools, scaling factors, model assumptions and correct concentrations.Physiologically based approaches towards the prediction of pharmacokinetics: in vitro-in vivo extrapolation.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Chiral enantioresolution of cathinone derivatives present in "legal highs", and enantioselectivity evaluation on cytotoxicity of 3,4-methylenedioxypyrovalerone (MDPV)Which in vitro models could be best used to study hepatocyte polarity?Cell sources for in vitro human liver cell culture models.
P2860
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P2860
The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The human hepatoma HepaRG cell ...... m and toxicity of xenobiotics.
@ast
The human hepatoma HepaRG cell ...... m and toxicity of xenobiotics.
@en
type
label
The human hepatoma HepaRG cell ...... m and toxicity of xenobiotics.
@ast
The human hepatoma HepaRG cell ...... m and toxicity of xenobiotics.
@en
prefLabel
The human hepatoma HepaRG cell ...... m and toxicity of xenobiotics.
@ast
The human hepatoma HepaRG cell ...... m and toxicity of xenobiotics.
@en
P2093
P1476
The human hepatoma HepaRG cell ...... m and toxicity of xenobiotics.
@en
P2093
André Guillouzo
Anne Corlu
Caroline Aninat
Christiane Guguen-Guillouzo
Denise Glaise
Fabrice Morel
P356
10.1016/J.CBI.2006.12.003
P4510
P577
2006-12-16T00:00:00Z