Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes
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Incomplete Re-Expression of Neuroendocrine Progenitor/Stem Cell Markers is a Key Feature of β-Cell Dedifferentiation.Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells.PAX6 maintains β cell identity by repressing genes of alternative islet cell types.LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells.Pancreatic β cell identity requires continual repression of non-β cell programs.Modeling Pancreatic Endocrine Cell Adaptation and Diabetes in the Zebrafish.Single-cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes.Metabolic Stress and Compromised Identity of Pancreatic Beta Cells.Evidence for Loss in Identity, De-Differentiation, and Trans-Differentiation of Islet β-Cells in Type 2 Diabetes.Temporal Changes in Gene Expression Profile during Mature Adipocyte Dedifferentiation.Identification of novel biomarkers to monitor β-cell function and enable early detection of type 2 diabetes risk.Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells?β-Cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion.Pair Feeding, but Not Insulin, Phloridzin, or Rosiglitazone Treatment, Curtails Markers of β-Cell Dedifferentiation in db/db Mice.Stress-induced adaptive islet cell identity changesShaping and preserving β-cell identity with microRNAs.Novel factors modulating human β-cell proliferation.β-Cell dysfunction in diabetes: a crisis of identity?Pancreatic β-cell identity in diabetes.When β-cells fail: lessons from dedifferentiation.Impact of Pdx1-associated chromatin modifiers on islet β-cells.Methods needed to measure predictive accuracy: A study of diabetic patients.The undoing and redoing of the diabetic β-cell.Genomics of Islet (Dys)function and Type 2 Diabetes.Pancreatic Beta Cell Identity in Humans and the Role of Type 2 Diabetes.Increased Hormone-Negative Endocrine Cells in the Pancreas in Type 1 Diabetes.Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice.Increased Frequency of Hormone Negative and Polyhormonal Endocrine Cells in Lean Individuals With Type 2 Diabetes.Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis.Interrogating islets in health and disease with single-cell technologiesDifferent developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth.Alpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterparts.db/db Mice Exhibit Features of Human Type 2 Diabetes That Are Not Present in Weight-Matched C57BL/6J Mice Fed a Western Diet.A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells.Islet cells share promoter hypomethylation independently of expression, but exhibit cell-type-specific methylation in enhancers.Preservation of Reduced Numbers of Insulin-Positive Cells in Sulfonylurea-Unresponsive KCNJ11-Related Diabetes.Loss of the imprinted, non-coding Snord116 gene cluster in the interval deleted in the Prader Willi syndrome results in murine neuronal and endocrine pancreatic developmental phenotypes.Epithelial to mesenchymal transition in human endocrine islet cells.Lower mean blood glucose during short-term intensive insulin therapy is associated with long-term glycemic remission in patients with newly diagnosed type 2 diabetes: Evidence-based recommendations for standardization.Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.
P2860
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P2860
Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes
@ast
Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes
@en
type
label
Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes
@ast
Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes
@en
prefLabel
Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes
@ast
Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes
@en
P2093
P2860
P356
P1476
Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes
@en
P2093
Francesca Cinti
Ja Young Kim-Muller
Lloyd E Ratner
Mara Suleiman
Matilde Masini
P R Sandoval
Piero Marchetti
Ryotaro Bouchi
Yoshiaki Ohmura
P2860
P304
P356
10.1210/JC.2015-2860
P407
P577
2015-12-29T00:00:00Z