Phosphatidic acid mediates demyelination in Lpin1 mutant mice. - Wikidata - awgldk - TriplyDB

Phosphatidic acid mediates demyelination in Lpin1 mutant mice.

Phosphatidic acid mediates demyelination in Lpin1 mutant mice.

http://www.wikidata.org/entity/Q36720957

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Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling Visualization of phosphatidic acid fluctuations in the plasma membrane of living cells Phosphorylation regulates the ubiquitin-independent degradation of yeast Pah1 phosphatidate phosphatase by the 20S proteasome.Yeast Nem1-Spo7 protein phosphatase activity on Pah1 phosphatidate phosphatase is specific for the Pho85-Pho80 protein kinase phosphorylation sites.New insights on Schwann cell development Sumoylation regulates nuclear localization of lipin-1alpha in neuronal cells.A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2 Lipin1 Regulates Skeletal Muscle Differentiation through Extracellular Signal-regulated Kinase (ERK) Activation and Cyclin D Complex-regulated Cell Cycle Withdrawal.Rhabdomyolysis-Associated Mutations in Human LPIN1 Lead to Loss of Phosphatidic Acid Phosphohydrolase Activity.Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue Relationship of glucose and oleate metabolism to cardiac function in lipin-1 deficient (fld) mice A hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodystrophy in the rat Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor γ coactivator 1α/estrogen related receptor axis.Dual function lipin proteins and glycerolipid metabolism Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice.Concurrent Lpin1 and Nrcam mouse mutations result in severe peripheral neuropathy with transitory hindlimb paralysis.SCAP is required for timely and proper myelin membrane synthesis.Isolation of novel animal cell lines defective in glycerolipid biosynthesis reveals mutations in glucose-6-phosphate isomerase.Mitogen Activated Protein Kinase Family Proteins and c-jun Signaling in Injury-induced Schwann Cell Plasticity.Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms.Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms Cross-talk phosphorylations by protein kinase C and Pho85p-Pho80p protein kinase regulate Pah1p phosphatidate phosphatase abundance in Saccharomyces cerevisiae.Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases.Gene expression patterns in four brain areas associate with quantitative measure of estrous behavior in dairy cows Phosphorylation of phosphatidate phosphatase regulates its membrane association and physiological functions in Saccharomyces cerevisiae: identification of SER(602), THR(723), AND SER(744) as the sites phosphorylated by CDC28 (CDK1)-encoded cyclin-de Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models.Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis.The discovery of the fat-regulating phosphatidic acid phosphatase gene Rac1 GTPase controls myelination and demyelination.Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in mice Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signaling Glucose-6-phosphate isomerase deficiency results in mTOR activation, failed translocation of lipin 1α to the nucleus and hypersensitivity to glucose: Implications for the inherited glycolytic disease Phosphatidate phosphatase activity plays key role in protection against fatty acid-induced toxicity in yeast.Lipin-1 phosphatidic phosphatase activity modulates phosphatidate levels to promote peroxisome proliferator-activated receptor γ (PPARγ) gene expression during adipogenesis.Fluorescence spectroscopy measures yeast PAH1-encoded phosphatidate phosphatase interaction with liposome membranes Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum.Altered Lipid Synthesis by Lack of Yeast Pah1 Phosphatidate Phosphatase Reduces Chronological Life Span.

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P2860

Phosphatidic acid mediates demyelination in Lpin1 mutant mice.

http://www.wikidata.org/entity/Q36720957

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Phosphatidic acid mediates demyelination in Lpin1 mutant mice.

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Phosphatidic acid mediates demyelination in Lpin1 mutant mice.

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type

label

Phosphatidic acid mediates demyelination in Lpin1 mutant mice.

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Phosphatidic acid mediates demyelination in Lpin1 mutant mice.

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prefLabel

Phosphatidic acid mediates demyelination in Lpin1 mutant mice.

@ast

Phosphatidic acid mediates demyelination in Lpin1 mutant mice.

@en

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Genes & Development

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Phosphatidic acid mediates demyelination in Lpin1 mutant mice.

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Anne-Sophie de Preux Charles

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George M Carman

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Gil-Soo Han

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Jean-Jacques Médard

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Jean-Sébastien Saulnier-Blache

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Karim Nadra

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Mark H G Verheijen

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Sandra Grès

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William T Hendriks

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P2860

Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin

Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin.

The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme.

Roles of phosphatidate phosphatase enzymes in lipid metabolism

Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns

Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway

Local regulation of fat metabolism in peripheral nerves.

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

A highly efficient recombineering-based method for generating conditional knockout mutations

Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1.

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10.1101/GAD.1638008

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12

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22

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5296214

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18559480

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2428062

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