Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylase.
about
Genotoxicants target distinct molecular networks in neonatal neuronsIncreasing DNA repair methyltransferase levels via bone marrow stem cell transduction rescues mice from the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea, a chemotherapeutic alkylating agentAlkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate.Release of normal bases from intact DNA by a native DNA repair enzyme.Imbalanced base excision repair increases spontaneous mutation and alkylation sensitivity in Escherichia coli.Generation of a strong mutator phenotype in yeast by imbalanced base excision repair.Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing.3-methyladenine-DNA-glycosylase and O6-alkyl guanine-DNA-alkyltransferase activities and sensitivity to alkylating agents in human cancer cell lines.Specific binding of a designed pyrrolidine abasic site analog to multiple DNA glycosylases.DNA repair functions in heterologous cells.Mismatch repair, G(2)/M cell cycle arrest and lethality after DNA damage.Mutational specificity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in Escherichia coli: comparison of in vivo with in vitro exposure of the supF gene.
P2860
Q28392440-D13A2AA0-BCD2-469D-8F3F-AC156A296E67Q33609622-57E29C5C-54D7-478E-A1D7-CE4EC71D9ED1Q33780508-95684FF2-B949-48DF-9D4A-231CAE84803FQ33888049-C981480A-58D7-46C9-AC15-D82C9A5CE5EEQ33993117-25205194-838E-42A1-A798-AB369939E290Q34750817-794693FE-4984-40B7-9540-6CCAFA4A0DBAQ35853590-A9B2027B-8ADC-40B8-A03C-165E245087F7Q36134289-6BD0358D-E0F8-42BC-9912-41D49ECC5F3AQ38337800-43ABBA0C-C80D-44EE-9A26-5D85AC23D538Q41311787-48F395D1-DCAD-492E-82BD-5397EB05EAAFQ53416148-E8E0BA52-E513-465B-AFF0-61D4869974CFQ54573303-E16B18D3-0B30-4ED8-ABD3-D5A68593BFB5
P2860
Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylase.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Protection against chloroethyl ...... methyladenine DNA glycosylase.
@ast
Protection against chloroethyl ...... methyladenine DNA glycosylase.
@en
type
label
Protection against chloroethyl ...... methyladenine DNA glycosylase.
@ast
Protection against chloroethyl ...... methyladenine DNA glycosylase.
@en
prefLabel
Protection against chloroethyl ...... methyladenine DNA glycosylase.
@ast
Protection against chloroethyl ...... methyladenine DNA glycosylase.
@en
P2093
P2860
P356
P1476
Protection against chloroethyl ...... methyladenine DNA glycosylase.
@en
P2093
D B Ludlum
M Boosalis
Z Matijasevic
P2860
P304
11855-11859
P356
10.1073/PNAS.90.24.11855
P407
P577
1993-12-01T00:00:00Z