Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease - Wikidata - awgldk - TriplyDB

Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease

Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease

http://www.wikidata.org/entity/Q36732009

about

Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region Mitochondrial dysfunction in inflammatory bowel disease Pregnane X receptor as a target for treatment of inflammatory bowel disorders Intestinal epithelium in inflammatory bowel disease Extensive expression differences along porcine small intestine evidenced by transcriptome sequencing Crosstalk of HNF4α with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipids Chemoprotective epigenetic mechanisms in a colorectal cancer model: Modulation by n-3 PUFA in combination with fermentable fiber Src tyrosine kinase phosphorylation of nuclear receptor HNF4α correlates with isoform-specific loss of HNF4α in human colon cancer.Loss of hepatocyte-nuclear-factor-4alpha affects colonic ion transport and causes chronic inflammation resembling inflammatory bowel disease in mice.Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease.Microbiota regulate intestinal epithelial gene expression by suppressing the transcription factor Hepatocyte nuclear factor 4 alpha Chromatin profiling reveals regulatory network shifts and a protective role for hepatocyte nuclear factor 4α during colitis.Mapping of liver-enriched transcription factors in the human intestine.Nuclear receptor HNF4α binding sequences are widespread in Alu repeats Hepatocyte nuclear factor-4 alpha regulates liver triglyceride metabolism in part through secreted phospholipase A₂ GXIIB.Inactivation of hepatocyte nuclear factor-4{alpha} mediates alcohol-induced downregulation of intestinal tight junction proteins.Modification in oxidative stress, inflammation, and lipoprotein assembly in response to hepatocyte nuclear factor 4alpha knockdown in intestinal epithelial cells.Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease modifier.Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation.An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis HNF4α regulates claudin-7 protein expression during intestinal epithelial differentiation.Amelioration of diabesity-induced colorectal ontogenesis by omega-3 fatty acids in mice.Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells.The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding.MicroRNA-feedback loop as a key modulator of liver tumorigenesis and inflammation.The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis.HNF4α: a new biomarker in colon cancer?The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer.Claudin-based barrier differentiation in the colonic epithelial crypt niche involves Hopx/Klf4 and Tcf7l2/Hnf4-α cascades Nutrient-Gene Interaction in Colon Cancer, from the Membrane to Cellular Physiology.Apoptosis signal-regulating kinase 1 mediates the inhibitory effect of hepatocyte nuclear factor-4α on hepatocellular carcinoma.Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation.Hepatocyte nuclear factor 4alpha, a key factor for homeostasis, cell architecture, and barrier function of the adult intestinal epithelium.Inflammatory bowel disease—from mechanisms to treatment strategies.Genetics of ulcerative colitis.Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics.Nuclear receptors in the cross-talk of drug metabolism and inflammation.

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P2860

Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease

http://www.wikidata.org/entity/Q36732009

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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name

Hepatocyte nuclear factor 4alp ...... nst inflammatory bowel disease

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Hepatocyte nuclear factor 4alp ...... nst inflammatory bowel disease

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type

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Hepatocyte nuclear factor 4alp ...... nst inflammatory bowel disease

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Hepatocyte nuclear factor 4alp ...... nst inflammatory bowel disease

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Hepatocyte nuclear factor 4alp ...... nst inflammatory bowel disease

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Hepatocyte nuclear factor 4alp ...... nst inflammatory bowel disease

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Inflammatory Bowel Diseases

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Hepatocyte nuclear factor 4alp ...... nst inflammatory bowel disease

@en

P2093

Frank J Gonzalez

http://www.w3.org/2001/XMLSchema#string

Insook Kim

http://www.w3.org/2001/XMLSchema#string

Junko Inoue

http://www.w3.org/2001/XMLSchema#string

Keiichirou Morimura

http://www.w3.org/2001/XMLSchema#string

Kunio Nagashima

http://www.w3.org/2001/XMLSchema#string

Reiko Kurotani

http://www.w3.org/2001/XMLSchema#string

Sung-Hoon Ahn

http://www.w3.org/2001/XMLSchema#string

Sunhee Yim

http://www.w3.org/2001/XMLSchema#string

Yatrik M Shah

http://www.w3.org/2001/XMLSchema#string

Yusuke Inoue

http://www.w3.org/2001/XMLSchema#string

P2860

Inflammatory Bowel Disease

Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes

Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4

Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin

Targeted disruption of the meprin beta gene in mice leads to underrepresentation of knockout mice and changes in renal gene expression profiles

Differential expression of aquaporin 8 in human colonic epithelial cells and colorectal tumors

Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4alpha (HNF4alpha) isoforms in human and rats

Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity

Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion

Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver

P304

908-920

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scholarly article

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10.1002/IBD.20413

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7

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14

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2008-07-01T00:00:00Z

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227742252

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18338782

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inflammatory bowel diseases

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2435391

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