Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease
about
Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human geneticsGenome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A regionMitochondrial dysfunction in inflammatory bowel diseasePregnane X receptor as a target for treatment of inflammatory bowel disordersIntestinal epithelium in inflammatory bowel diseaseExtensive expression differences along porcine small intestine evidenced by transcriptome sequencingCrosstalk of HNF4α with extracellular and intracellular signaling pathways in the regulation of hepatic metabolism of drugs and lipidsChemoprotective epigenetic mechanisms in a colorectal cancer model: Modulation by n-3 PUFA in combination with fermentable fiberSrc tyrosine kinase phosphorylation of nuclear receptor HNF4α correlates with isoform-specific loss of HNF4α in human colon cancer.Loss of hepatocyte-nuclear-factor-4alpha affects colonic ion transport and causes chronic inflammation resembling inflammatory bowel disease in mice.Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease.Microbiota regulate intestinal epithelial gene expression by suppressing the transcription factor Hepatocyte nuclear factor 4 alphaChromatin profiling reveals regulatory network shifts and a protective role for hepatocyte nuclear factor 4α during colitis.Mapping of liver-enriched transcription factors in the human intestine.Nuclear receptor HNF4α binding sequences are widespread in Alu repeatsHepatocyte nuclear factor-4 alpha regulates liver triglyceride metabolism in part through secreted phospholipase A₂ GXIIB.Inactivation of hepatocyte nuclear factor-4{alpha} mediates alcohol-induced downregulation of intestinal tight junction proteins.Modification in oxidative stress, inflammation, and lipoprotein assembly in response to hepatocyte nuclear factor 4alpha knockdown in intestinal epithelial cells.Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease modifier.Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation.An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesisHNF4α regulates claudin-7 protein expression during intestinal epithelial differentiation.Amelioration of diabesity-induced colorectal ontogenesis by omega-3 fatty acids in mice.Differential Effects of Hepatocyte Nuclear Factor 4α Isoforms on Tumor Growth and T-Cell Factor 4/AP-1 Interactions in Human Colorectal Cancer Cells.The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel diseaseIntestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding.MicroRNA-feedback loop as a key modulator of liver tumorigenesis and inflammation.The metalloproteases meprin α and meprin β: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis.HNF4α: a new biomarker in colon cancer?The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adultsOpposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer.Claudin-based barrier differentiation in the colonic epithelial crypt niche involves Hopx/Klf4 and Tcf7l2/Hnf4-α cascadesNutrient-Gene Interaction in Colon Cancer, from the Membrane to Cellular Physiology.Apoptosis signal-regulating kinase 1 mediates the inhibitory effect of hepatocyte nuclear factor-4α on hepatocellular carcinoma.Dietary docosahexaenoic and eicosapentaenoic acid: emerging mediators of inflammation.Hepatocyte nuclear factor 4alpha, a key factor for homeostasis, cell architecture, and barrier function of the adult intestinal epithelium.Inflammatory bowel disease—from mechanisms to treatment strategies.Genetics of ulcerative colitis.Determinants of colonic barrier function in inflammatory bowel disease and potential therapeutics.Nuclear receptors in the cross-talk of drug metabolism and inflammation.
P2860
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P2860
Hepatocyte nuclear factor 4alpha in the intestinal epithelial cells protects against inflammatory bowel disease
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Hepatocyte nuclear factor 4alp ...... nst inflammatory bowel disease
@ast
Hepatocyte nuclear factor 4alp ...... nst inflammatory bowel disease
@en
type
label
Hepatocyte nuclear factor 4alp ...... nst inflammatory bowel disease
@ast
Hepatocyte nuclear factor 4alp ...... nst inflammatory bowel disease
@en
prefLabel
Hepatocyte nuclear factor 4alp ...... nst inflammatory bowel disease
@ast
Hepatocyte nuclear factor 4alp ...... nst inflammatory bowel disease
@en
P2093
P2860
P356
P1476
Hepatocyte nuclear factor 4alp ...... nst inflammatory bowel disease
@en
P2093
Frank J Gonzalez
Insook Kim
Junko Inoue
Keiichirou Morimura
Kunio Nagashima
Reiko Kurotani
Sung-Hoon Ahn
Sunhee Yim
Yatrik M Shah
Yusuke Inoue
P2860
P304
P356
10.1002/IBD.20413
P577
2008-07-01T00:00:00Z