A periodic pattern of evolutionarily conserved basic and acidic residues constitutes the binding interface of actin-tropomyosin
about
Vascular disease-causing mutation R258C in ACTA2 disrupts actin dynamics and interaction with myosinMyosin motor isoforms direct specification of actomyosin function by tropomyosins.The structural dynamics of α-tropomyosin on F-actin shape the overlap complex between adjacent tropomyosin molecules.An atomic model of the tropomyosin cable on F-actinStructural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin.Altered interactions between cardiac myosin binding protein-C and α-cardiac actin variants associated with cardiomyopathiesA molecular evolution approach to study the roles of tropomyosin in fission yeast.Pseudo-acetylation of K326 and K328 of actin disrupts Drosophila melanogaster indirect flight muscle structure and performanceProbing the flexibility of tropomyosin and its binding to filamentous actin using molecular dynamics simulationsGestalt-binding of tropomyosin on actin during thin filament activation.Periodicities designed in the tropomyosin sequence and structure define its functions.Tropomyosin dynamics.Insights into the effects of disease-causing mutations in human actins.Thin Filament Structure and the Steric Blocking Model.Using baculovirus/insect cell expressed recombinant actin to study the molecular pathogenesis of HCM caused by actin mutation A331PTropomyosin Structure, Function, and Interactions: A Dynamic Regulator.The impact of tropomyosins on actin filament assembly is isoform specific.Tropomyosin movement on F-actin during muscle activation explained by energy landscapesEvolutionarily conserved sites in yeast tropomyosin function in cell polarity, transport and contractile ring formation.Structural differences between C-terminal regions of tropomyosin isoforms.Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks.Severe Molecular Defects Exhibited by the R179H Mutation in Human Vascular Smooth Muscle α-Actin.Tropomyosin diffusion over actin subunits facilitates thin filament assembly.Skeletal muscle myopathy mutations at the actin tropomyosin interface that cause gain- or loss-of-function.Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function.Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy.Investigating the effects of tropomyosin mutations on its flexibility and interactions with filamentous actin using molecular dynamics simulation.Distinct sites in tropomyosin specify shared and isoform-specific regulation of myosins II and V.
P2860
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P2860
A periodic pattern of evolutionarily conserved basic and acidic residues constitutes the binding interface of actin-tropomyosin
description
2013 nî lūn-bûn
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2013年の論文
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2013年論文
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2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
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2013年论文
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2013年论文
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name
A periodic pattern of evolutio ...... interface of actin-tropomyosin
@ast
A periodic pattern of evolutio ...... interface of actin-tropomyosin
@en
type
label
A periodic pattern of evolutio ...... interface of actin-tropomyosin
@ast
A periodic pattern of evolutio ...... interface of actin-tropomyosin
@en
prefLabel
A periodic pattern of evolutio ...... interface of actin-tropomyosin
@ast
A periodic pattern of evolutio ...... interface of actin-tropomyosin
@en
P2093
P2860
P356
P1476
A periodic pattern of evolutio ...... interface of actin-tropomyosin
@en
P2093
Bipasha Barua
Donald A Winkelmann
Kathleen M Trybus
Patricia M Fagnant
Sarah E Hitchcock-DeGregori
P2860
P304
P356
10.1074/JBC.M113.451161
P407
P577
2013-02-18T00:00:00Z