Local destabilization of the tropomyosin coiled coil gives the molecular flexibility required for actin binding
about
Structure of the N Terminus of a Nonmuscle α-Tropomyosin in Complex with the C Terminus: Implications for Actin Binding † ‡Structural Analysis of Smooth Muscle Tropomyosin and IsoformsActin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chainThin filament mutations: developing an integrative approach to a complex disorderThermal unfolding of smooth muscle and nonmuscle tropomyosin alpha-homodimers with alternatively spliced exonsClinically Divergent Mutation Effects on the Structure and Function of the Human Cardiac Tropomyosin Overlap.Phosphorylation of tropomyosin extends cooperative binding of myosin beyond a single regulatory unitRegulation of nonmuscle myosin II by tropomyosin.A peek into tropomyosin binding and unfolding on the actin filament.Critical interactions in the stability control region of tropomyosin.The relationship between curvature, flexibility and persistence length in the tropomyosin coiled-coilCurvature variation along the tropomyosin molecule.A myopathy-linked tropomyosin mutation severely alters thin filament conformational changes during activation.Effects of two familial hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on the thermal unfolding of actin-bound tropomyosin.Structure of the mid-region of tropomyosin: bending and binding sites for actinEnhanced active cross-bridges during diastole: molecular pathogenesis of tropomyosin's HCM mutationsStructural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin.Evolutionarily conserved surface residues constitute actin binding sites of tropomyosin.A periodic pattern of evolutionarily conserved basic and acidic residues constitutes the binding interface of actin-tropomyosinTropomyosin dynamics in cardiac thin filaments: a multisite forster resonance energy transfer and anisotropy study.Conserved Asp-137 is important for both structure and regulatory functions of cardiac α-tropomyosin (α-TM) in a novel transgenic mouse model expressing α-TM-D137LAn internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivityTransmission of stability information through the N-domain of tropomyosin is interrupted by a stabilizing mutation (A109L) in the hydrophobic core of the stability control region (residues 97-118).New insights into the regulation of the actin cytoskeleton by tropomyosin.Gestalt-binding of tropomyosin on actin during thin filament activation.A study of tropomyosin's role in cardiac function and disease using thin-filament reconstituted myocardium.Maladaptive modifications in myofilament proteins and triggers in the progression to heart failure and sudden death.Tropomyosin dynamics.The cardiomyopathy-associated K15N mutation in tropomyosin alters actin filament pointed end dynamics.Tropomyosin Structure, Function, and Interactions: A Dynamic Regulator.Myofibrillar troponin exists in three states and there is signal transduction along skeletal myofibrillar thin filaments.The role of tropomyosin domains in cooperative activation of the actin-myosin interaction.What makes tropomyosin an actin binding protein? A perspective.How sequence directs bending in tropomyosin and other two-stranded alpha-helical coiled coils.Interaction sites of tropomyosin in muscle thin filament as identified by site-directed spin-labeling.Identification of a unique "stability control region" that controls protein stability of tropomyosin: A two-stranded alpha-helical coiled-coil.Push and pull of tropomyosin's opposite effects on myosin attachment to actin. A chimeric tropomyosin host-guest studyDifferent effects of trifluoroethanol and glycerol on the stability of tropomyosin helices and the head-to-tail complex.Using circular dichroism collected as a function of temperature to determine the thermodynamics of protein unfolding and binding interactionsTropomyosin period 3 is essential for enhancement of isometric tension in thin filament-reconstituted bovine myocardium.
P2860
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P2860
Local destabilization of the tropomyosin coiled coil gives the molecular flexibility required for actin binding
description
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Dezember 2003 veröffentlicher wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/12/09)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/12/09)
@nl
наукова стаття, опублікована в грудні 2003
@uk
مقالة علمية (نشرت في 9-12-2003)
@ar
name
Local destabilization of the t ...... ity required for actin binding
@ast
Local destabilization of the t ...... ity required for actin binding
@en
Local destabilization of the t ...... ity required for actin binding
@nl
type
label
Local destabilization of the t ...... ity required for actin binding
@ast
Local destabilization of the t ...... ity required for actin binding
@en
Local destabilization of the t ...... ity required for actin binding
@nl
prefLabel
Local destabilization of the t ...... ity required for actin binding
@ast
Local destabilization of the t ...... ity required for actin binding
@en
Local destabilization of the t ...... ity required for actin binding
@nl
P356
P1433
P1476
Local destabilization of the t ...... ity required for actin binding
@en
P2093
Abhishek Singh
Sarah E. Hitchcock-DeGregori
P304
14114–14121
P356
10.1021/BI0348462
P407
P577
2003-12-09T00:00:00Z