Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets - Wikidata - awgldk - TriplyDB

Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

http://www.wikidata.org/entity/Q36742299

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Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration Exploitation of differential homeostatic proliferation of T-cell subsets following chemotherapy to enhance the efficacy of vaccine-mediated antitumor responses Adoptive T-Cell Immunotherapy CD1d- and MR1-Restricted T Cells in Sepsis Interleukin-7 and interleukin-15 for cancer Advances in the management of sepsis and the understanding of key immunologic defects Reversing T cell immunosenescence: why, who, and how Incomplete immune recovery in HIV infection: mechanisms, relevance for clinical care, and possible solutions Mechanisms shaping the naïve T cell repertoire in the elderly - thymic involution or peripheral homeostatic proliferation?Lentiviral vector delivery of human interleukin-7 (hIL-7) to human immune system (HIS) mice expands T lymphocyte populations Establishment and Maintenance of the Human Naïve CD4+ T-Cell Compartment Mechanism of Action of IL-7 and Its Potential Applications and Limitations in Cancer Immunotherapy Chemo-immunotherapy with oxaliplatin and interleukin-7 inhibits colon cancer metastasis in mice Occurrence of Anti-Drug Antibodies against Interferon-Beta and Natalizumab in Multiple Sclerosis: A Collaborative Cohort Analysis Progressive activation of CD127+132- recent thymic emigrants into terminally differentiated CD127-132+ T-cells in HIV-1 infection Emerging therapeutic targets of sepsis-associated acute kidney injury.CD8+ T-cell interleukin-7 receptor alpha expression as a potential indicator of disease status in HIV-infected children.Impact of growth hormone (GH) deficiency and GH replacement upon thymus function in adult patients.Development of a quantitative bead capture assay for soluble IL-7 receptor alpha in human plasma.Modulating T-cell homeostasis with IL-7: preclinical and clinical studies.Engineered T cells for cancer treatment Interleukin-7 and Immunosenescence.Phase I study of recombinant human interleukin-7 administration in subjects with refractory malignancy.Concurrent vaccination with two distinct vaccine platforms targeting the same antigen generates phenotypically and functionally distinct T-cell populations.Immune-based therapeutics for pediatric cancer.Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival.New insights into the regulation of T cells by gamma(c) family cytokines Quantifying and predicting the effect of exogenous interleukin-7 on CD4+ T cells in HIV-1 infection.An overview of IL-7 biology and its use in immunotherapy.Cytokines as Adjuvants for Vaccine and Cellular Therapies for Cancer.T-cell-based therapies for malignancy and infection in childhood.Potential contribution of IL-7 to allergen-induced eosinophilic airway inflammation in asthma Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation.The interaction of LCK and the CD4 co-receptor alters the dose response of T-cells to interleukin-7.Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response.IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis.Crucial roles of interleukin-7 in the development of T follicular helper cells and in the induction of humoral immunity.Immune senescence in aged nonhuman primates IL-7 promotes CD95-induced apoptosis in B cells via the IFN-γ/STAT1 pathway.Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor.

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P2860

Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets

http://www.wikidata.org/entity/Q36742299

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Andrew Pecora

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Catherine K Chow

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Claude Sportès

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Crystal L Mackall

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David J Venzon

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Frances T Hakim

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Hua Zhang

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Julie Engels

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Kevin S Chua

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Margaret R Brown

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P2860

Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency

Age-dependent incidence, time course, and consequences of thymic renewal in adults

IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells

IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells

Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis

Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice

Central memory and effector memory T cell subsets: function, generation, and maintenance

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution.

Interleukin-7 improves T-cell recovery after experimental T-cell-depleted bone marrow transplantation in T-cell-deficient mice by strong expansion of recent thymic emigrants.

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1701-1714

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10.1084/JEM.20071681

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7

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205

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Michael Krumlauf

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5282325

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18573906

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2442646

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