Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells.
about
Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channelDiabetes reduces autophosphorylation of retinal insulin receptor and increases protein-tyrosine phosphatase-1B activityPhotoreceptors in diabetic retinopathyRegulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteinsSerine/threonine kinase akt activation regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPLEnhanced retinal insulin receptor-activated neuroprotective survival signal in mice lacking the protein-tyrosine phosphatase-1B gene.Phosphoinositides: minor lipids make a major impact on photoreceptor cell functions.Rhodopsin-regulated insulin receptor signaling pathway in rod photoreceptor neurons.Deletion of the p85alpha regulatory subunit of phosphoinositide 3-kinase in cone photoreceptor cells results in cone photoreceptor degeneration.Non-canonical regulation of phosphatidylinositol 3-kinase gamma isoform activity in retinal rod photoreceptor cellsPhosphoinositide 3-kinase signaling in retinal rod photoreceptors.Phosphorylated Grb14 is an endogenous inhibitor of retinal protein tyrosine phosphatase 1B, and light-dependent activation of Src phosphorylates Grb14.Phosphoinositides and photoreceptors.Insulin signaling in retinal neurons is regulated within cholesterol-enriched membrane microdomains.Transgenic Mice Overexpressing Serum Retinol-Binding Protein Develop Progressive Retinal Degeneration through a Retinoid-Independent Mechanism.Proinsulin slows retinal degeneration and vision loss in the P23H rat model of retinitis pigmentosaInsulin receptor signaling in cones.Activation and membrane binding of retinal protein kinase Balpha/Akt1 is regulated through light-dependent generation of phosphoinositidesInsulin growth factor 1 receptor/PI3K/AKT survival pathway in outer segment membranes of rod photoreceptors.Insulin receptor regulates photoreceptor CNG channel activity.Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotectionInsulin receptor signaling regulates actin cytoskeletal organization in developing photoreceptors.Cytoskeletal components enhance the autophosphorylation of retinal insulin receptor.Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation.Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptorsPhosphoinositide 3-kinase signaling in the vertebrate retina.Activation of oncogenic tyrosine kinase signaling promotes insulin receptor-mediated cone photoreceptor survival.R9AP overexpression alters phototransduction kinetics in iCre75 mice.Neuroprotective Strategy in Retinal Degeneration: Suppressing ER Stress-Induced Cell Death via Inhibition of the mTOR Signal.Conditional gene targeting: dissecting the cellular mechanisms of retinal degenerations.Loss of daylight vision in retinal degeneration: are oxidative stress and metabolic dysregulation to blame?Protein tyrosine phosphatase 1B: a novel molecular target for retinal degenerative diseases.Tissue-specific insulin signaling, metabolic syndrome, and cardiovascular disease.Diabetic retinopathy: loss of neuroretinal adaptation to the diabetic metabolic environment.Progressive Rod-Cone Degeneration (PRCD) Protein Requires N-Terminal S-Acylation and Rhodopsin Binding for Photoreceptor Outer Segment Localization and Maintaining Intracellular Stability.Imatinib induces apoptosis by inhibiting PDGF- but not insulin-induced PI 3-kinase/Akt survival signaling in RGC-5 retinal ganglion cells.Light, lipids and photoreceptor survival: live or let die?Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival.Loss of Shp2-mediated mitogen-activated protein kinase signaling in Muller glial cells results in retinal degeneration.Expression of Cre recombinase in retinal Müller cells.
P2860
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P2860
Loss of neuroprotective survival signal in mice lacking insulin receptor gene in rod photoreceptor cells.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Loss of neuroprotective surviv ...... ne in rod photoreceptor cells.
@ast
Loss of neuroprotective surviv ...... ne in rod photoreceptor cells.
@en
type
label
Loss of neuroprotective surviv ...... ne in rod photoreceptor cells.
@ast
Loss of neuroprotective surviv ...... ne in rod photoreceptor cells.
@en
prefLabel
Loss of neuroprotective surviv ...... ne in rod photoreceptor cells.
@ast
Loss of neuroprotective surviv ...... ne in rod photoreceptor cells.
@en
P2093
P2860
P356
P1476
Loss of neuroprotective surviv ...... ne in rod photoreceptor cells.
@en
P2093
Ammaji Rajala
Masaki Tanito
Raju V S Rajala
P2860
P304
19781-19792
P356
10.1074/JBC.M802374200
P407
P577
2008-05-14T00:00:00Z