The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development.
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T cell receptor signalling in the control of regulatory T cell differentiation and functionControl of the thymic medulla and its influence on αβT-cell developmentThymic Crosstalk Coordinates Medulla Organization and T-Cell Tolerance InductionMaturation and migration of murine CD4 single positive thymocytes and thymic emigrantsDevelopment of thymic Foxp3(+) regulatory T cells: TGF-β mattersDifferential requirement for CCR4 in the maintenance but not establishment of the invariant Vγ5(+) dendritic epidermal T-cell poolEvolving strategies for cancer and autoimmunity: back to the futurePositive and negative selection of the T cell repertoire: what thymocytes see (and don't see)Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns.Conserved and divergent aspects of human T-cell development and migration in humanized miceUnique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells.Differential requirement for CCR4 and CCR7 during the development of innate and adaptive αβT cells in the adult thymus.Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymusBiology of the RANKL-RANK-OPG System in Immunity, Bone, and Beyond.Limitation of immune tolerance-inducing thymic epithelial cell development by Spi-B-mediated negative feedback regulationModels of self-peptide sampling by developing T cells identify candidate mechanisms of thymic selection.The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function.The thymic cortical epithelium determines the TCR repertoire of IL-17-producing γδT cells.Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells.Stat3 Signaling Promotes Survival And Maintenance Of Medullary Thymic Epithelial Cells.mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ RecombinationHuman thymus medullary epithelial cells promote regulatory T-cell generation by stimulating interleukin-2 production via ICOS ligandNatural Th17 cells are critically regulated by functional medullary thymic microenvironments.The Prerequisites for Central Tolerance Induction against Citrullinated Proteins in the MouseCCR7 Controls Thymus Recirculation, but Not Production and Emigration, of Foxp3(+) T CellsIncreased generation of Foxp3(+) regulatory T cells by manipulating antigen presentation in the thymus.An Essential Role for the Transcription Factor Runx1 in T Cell MaturationDynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla.Late stages of T cell maturation in the thymus involve NF-κB and tonic type I interferon signalingDifferential requirement for IL-2 and IL-15 during bifurcated development of thymic regulatory T cellsmTORC2 in Thymic Epithelial Cells Controls Thymopoiesis and T Cell Development.Peripheral and thymic foxp3(+) regulatory T cells in search of origin, distinction, and functionMaturation and emigration of single-positive thymocytes.Thymocyte apoptosis drives the intrathymic generation of regulatory T cells.An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells.It's time to bring dendritic cell therapy to type 1 diabetes.Regulations of gene expression in medullary thymic epithelial cells required for preventing the onset of autoimmune diseases.The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance.Thymus medulla fosters generation of natural Treg cells, invariant γδ T cells, and invariant NKT cells: what we learn from intrathymic migration.The contribution of NF-κB signalling to immune regulation and tolerance.
P2860
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P2860
The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
The thymic medulla is required ...... al CD4+ thymocyte development.
@en
type
label
The thymic medulla is required ...... al CD4+ thymocyte development.
@en
prefLabel
The thymic medulla is required ...... al CD4+ thymocyte development.
@en
P2093
P2860
P50
P356
P1476
The thymic medulla is required ...... al CD4+ thymocyte development.
@en
P2093
Eric J Jenkinson
Jennifer E Cowan
Kyoko Nakamura
Peter J L Lane
Sonia M Parnell
P2860
P304
P356
10.1084/JEM.20122070
P407
P577
2013-03-25T00:00:00Z