Estrogen receptor-alpha hinge-region lysines 302 and 303 regulate receptor degradation by the proteasome
about
Lysosomal function is involved in 17β-estradiol-induced estrogen receptor α degradation and cell proliferationSent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease.Ligands specify estrogen receptor alpha nuclear localization and degradationOestrogens and spermatogenesis.Synthesis and characterization of fluorescent 4-hydroxytamoxifen conjugates with unique antiestrogenic propertiesTrichostatin A enhances acetylation as well as protein stability of ERalpha through induction of p300 protein.Research resource: comparison of gene profiles from wild-type ERα and ERα hinge region mutants.The atypical ubiquitin ligase RNF31 stabilizes estrogen receptor α and modulates estrogen-stimulated breast cancer cell proliferationEstrogen receptor mutations and changes in downstream gene expression and signalingSelectively targeting estrogen receptors for cancer treatment.Apigenin manipulates the ubiquitin-proteasome system to rescue estrogen receptor-β from degradation and induce apoptosis in prostate cancer cells.The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer.C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection.Target points in trastuzumab resistanceTumor suppressor function of RUNX3 in breast cancerPhosphorylation by p38 mitogen-activated protein kinase promotes estrogen receptor α turnover and functional activity via the SCF(Skp2) proteasomal complex.G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression.pRb controls estrogen receptor alpha protein stability and activity.Regulation of estrogen receptor α by histone methyltransferase SMYD2-mediated protein methylationOTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activityEpigenetics meets estrogen receptor: regulation of estrogen receptor by direct lysine methylation.An H2A histone isotype regulates estrogen receptor target genes by mediating enhancer-promoter-3'-UTR interactions in breast cancer cells.Ligand binding promotes CDK-dependent phosphorylation of ER-alpha on hinge serine 294 but inhibits ligand-independent phosphorylation of serine 305.Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells.SHARPIN stabilizes estrogen receptor α and promotes breast cancer cell proliferation.ERpS294 is a biomarker of ligand or mutational ERα activation and a breast cancer target for CDK2 inhibition.Intrinsic ubiquitin E3 ligase activity of histone acetyltransferase Hbo1 for estrogen receptor α.Experimental models for evaluating non-genomic estrogen signaling.Structural insights into tumor-specific chaperoning activity of gamma synuclein in protecting estrogen receptor alpha 36 and its role in tamoxifen resistance in breast cancer.Polyubiquitination inhibition of estrogen receptor alpha and its implications in breast cancer
P2860
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P2860
Estrogen receptor-alpha hinge-region lysines 302 and 303 regulate receptor degradation by the proteasome
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Estrogen receptor-alpha hinge- ...... degradation by the proteasome
@ast
Estrogen receptor-alpha hinge- ...... degradation by the proteasome
@en
type
label
Estrogen receptor-alpha hinge- ...... degradation by the proteasome
@ast
Estrogen receptor-alpha hinge- ...... degradation by the proteasome
@en
prefLabel
Estrogen receptor-alpha hinge- ...... degradation by the proteasome
@ast
Estrogen receptor-alpha hinge- ...... degradation by the proteasome
@en
P2093
P2860
P356
P1476
Estrogen receptor-alpha hinge- ...... degradation by the proteasome
@en
P2093
Kenneth P Nephew
Meiyun Fan
Nicholas B Berry
P2860
P304
P356
10.1210/ME.2007-0449
P577
2008-04-03T00:00:00Z