Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase
about
RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitinationRegulation of Unperturbed DNA Replication by UbiquitylationDeregulation of F-box proteins and its consequence on cancer development, progression and metastasis.14-3-3 proteins play a role in the cell cycle by shielding cdt2 from ubiquitin-mediated degradationRegulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation.A Proteome-wide Domain-centric Perspective on Protein Phosphorylation.The stress phenotype makes cancer cells addicted to CDT2, a substrate receptor of the CRL4 ubiquitin ligase.CDK1-dependent inhibition of the E3 ubiquitin ligase CRL4CDT2 ensures robust transition from S Phase to Mitosis.Roles of F-box proteins in cancerFBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development.Robustness of cell cycle control and flexible orders of signaling eventsInteractions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung.Small molecule therapeutics targeting F-box proteins in cancer.Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteinsMechanisms and function of substrate recruitment by F-box proteins.Regulation of stem cell function by protein ubiquitylationThe ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer.Switching off key signaling survival molecules to switch on the resolution of inflammation.SCF ubiquitin ligase-targeted therapies.MicroRNA regulation of F-box proteins and its role in cancer.DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver.Targeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells.Identification of a tumor suppressor network in T-cell leukemia.
P2860
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P2860
Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Regulation of the CRL4(Cdt2) u ...... e SCF(Fbxo11) ubiquitin ligase
@ast
Regulation of the CRL4(Cdt2) u ...... e SCF(Fbxo11) ubiquitin ligase
@en
type
label
Regulation of the CRL4(Cdt2) u ...... e SCF(Fbxo11) ubiquitin ligase
@ast
Regulation of the CRL4(Cdt2) u ...... e SCF(Fbxo11) ubiquitin ligase
@en
prefLabel
Regulation of the CRL4(Cdt2) u ...... e SCF(Fbxo11) ubiquitin ligase
@ast
Regulation of the CRL4(Cdt2) u ...... e SCF(Fbxo11) ubiquitin ligase
@en
P2093
P2860
P50
P1433
P1476
Regulation of the CRL4(Cdt2) u ...... e SCF(Fbxo11) ubiquitin ligase
@en
P2093
Adam Antebi
Anita Saraf
Moritz Horn
Shanshan Duan
Yeon-Tae Jeong
P2860
P304
P356
10.1016/J.MOLCEL.2013.02.004
P577
2013-03-07T00:00:00Z