The investigational Aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo.
about
Muscle-invasive urothelial bladder cancer: an update on systemic therapyScientific Rationale Supporting the Clinical Development Strategy for the Investigational Aurora A Kinase Inhibitor Alisertib in CancerAlisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cellsGene profiling suggests a common evolution of bladder cancer subtypesThe Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidyIssues in interpreting the in vivo activity of Aurora-AAlisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cellsThe pan-inhibitor of Aurora kinases danusertib induces apoptosis and autophagy and suppresses epithelial-to-mesenchymal transition in human breast cancer cellsp53 Family Members Regulate Phenotypic Response to Aurora Kinase A Inhibition in Triple-Negative Breast CancerAlisertib Induces Cell Cycle Arrest, Apoptosis, Autophagy and Suppresses EMT in HT29 and Caco-2 Cells.Aurora kinase targeting in lung cancer reduces KRAS-induced transformation.The p38 MAPK inhibitor BIRB796 enhances the antitumor effects of VX680 in cervical cancer.Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer.Cucurbitacin B exerts anti-cancer activities in human multiple myeloma cells in vitro and in vivo by modulating multiple cellular pathways.The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation.Plakophilins in desmosomal adhesion and signaling.The route to personalized medicine in bladder cancer: where do we stand?Targeted therapies in bladder cancer: an overview of in vivo research.The Aurora kinase inhibitors in cancer research and therapy.Kinase signaling and targeted therapy for primary myelofibrosis.An update on the pharmacokinetics and pharmacodynamics of alisertib, a selective Aurora kinase A inhibitor.Open-label, multicenter, phase 1 study of alisertib (MLN8237), an aurora A kinase inhibitor, with docetaxel in patients with solid tumors.Aurora-A Kinase: A Potent Oncogene and Target for Cancer Therapy.Urothelial Bladder Cancer Urinary Biomarkers.Involvement of caspase-2 activation in aurora kinase inhibitor-induced cell death in axin-expressing L929 cells.A SILAC-based proteomics elicits the molecular interactome of alisertib (MLN8237) in human erythroleukemia K562 cells.Aurora kinase A is essential for correct chromosome segregation in mouse zygote.An open-label, single-arm, phase 2 study of the Aurora kinase A inhibitor alisertib in patients with advanced urothelial cancer.Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain.Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase-Mediated Eukaryotic Initiation Factor 2α Activity and Is Targetable by Pegylated Arginine Deiminase.Aurora A Functional Single Nucleotide Polymorphism (SNP) Correlates With Clinical Outcome in Patients With Advanced Solid Tumors Treated With Alisertib, an Investigational Aurora A Kinase Inhibitor.Concurrent Inhibition of Neurosphere and Monolayer Cells of Pediatric Glioblastoma by Aurora A Inhibitor MLN8237 Predicted Survival Extension in PDOX models.MicroRNA-124-3p affects proliferation, migration and apoptosis of bladder cancer cells through targeting AURKA.Pathology and molecular updates in tumors of the prostate: towards a personalized approach.Aurora A Kinase as a diagnostic urinary marker for urothelial bladder cancer.Functional analysis of gene expression profiling-based prediction in bladder cancer.
P2860
Q26775780-5F3CDE87-77E8-4F8B-81FD-B15137F25FBFQ26784060-9E4A5786-B585-4E1B-9030-1D28103307B6Q28386389-192D636F-3EAF-408F-902C-6D0B5FDB4DDBQ33589389-92949FC3-1A5A-4EFE-AA2D-905D8DBEFEE5Q34227665-E2F0C550-E65A-4178-BA74-57C78A957D49Q34964087-F2B2AC58-C464-4BED-AE93-123F4B020A8BQ34977484-2A824E3F-C4C0-4AAF-9854-F82BC7791C62Q35115300-818EE290-8C1C-41DB-B32E-698DF27304D2Q35587605-AB09EAA1-221C-40F7-872A-19BA12E3E362Q36512454-1AFEFD7E-C2F1-4C7F-9E70-05D67C3FE673Q36538710-61AD7554-DFEA-46BE-B1A7-4871C33E00E6Q37013275-80A7268C-95C3-45FA-A8B3-709F684C3335Q37580388-55786111-0E4C-47FA-9726-F823E44C3D52Q37701484-184E87C2-441F-4135-B5FD-0424A65A2E2EQ37709004-32347502-A0DE-42E1-9417-DBBB9D14667EQ38181535-74293598-4091-4864-90F7-DABD425E4209Q38337192-E020BA7E-8F5F-441F-BA34-C734C9A46692Q38590471-59D8E70F-6822-48F0-8B10-BBB3C20C93D3Q38756932-A8B2A7AA-7558-482B-8C7F-08564A9C24E6Q38775472-DC26258E-F001-4FFD-BAAF-453DB00B53E2Q38783162-0D8BC111-DF49-497E-A64D-D53D38BDD7CCQ38865758-247EB304-300E-4CA6-B78A-96846901F70BQ38894287-50E28F1D-FEC9-4117-942D-1727B02BC372Q38967481-FAFF1864-3272-4653-906F-156B4849DDC4Q39052359-8170A904-F432-4658-A918-DF8104F3AEA4Q40065746-E206AAD6-9588-459A-8C41-17B3A332EFC7Q40736999-504B2A46-2E74-424C-BFE7-24402F30E446Q40912134-C525076E-1A76-4162-9CA3-E51A85358EE4Q41868025-60D9D945-18FE-4A17-A46B-F9BE2FD6ED1DQ46197347-4382CE0A-688D-4DFF-9971-488C5F6DF1C7Q47104548-8C93517F-576E-4F5B-B0B5-161D8A2386B0Q49791882-F214E685-B0DF-4FEA-A55F-BC12E046E31EQ52783509-A84E4B4C-006D-4AF0-BDA7-038A40C1E9ACQ52861100-C1EF9488-224E-4972-9702-E36F28410180Q54375562-3ACC4D68-DFAF-4288-A4BB-B05C058BF3C1Q55324270-036A2D80-45FB-4794-B6B2-F0C26419DC1D
P2860
The investigational Aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
The investigational Aurora kin ...... er cells in vitro and in vivo.
@ast
The investigational Aurora kin ...... er cells in vitro and in vivo.
@en
type
label
The investigational Aurora kin ...... er cells in vitro and in vivo.
@ast
The investigational Aurora kin ...... er cells in vitro and in vivo.
@en
prefLabel
The investigational Aurora kin ...... er cells in vitro and in vivo.
@ast
The investigational Aurora kin ...... er cells in vitro and in vivo.
@en
P2093
P2860
P1476
The investigational Aurora kin ...... cer cells in vitro and in vivo
@en
P2093
Daniel Lindner
Donna E Hansel
Jeffrey A Ecsedy
Kamini Singh
Maria C Mir
Robert Dreicer
Yvonne Parker
Zhongfa Zhang
P2860
P304
P356
10.1158/1078-0432.CCR-12-2383
P407
P577
2013-02-12T00:00:00Z