The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells
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Exome sequencing identifies recurrent somatic RAC1 mutations in melanomaScientific Rationale Supporting the Clinical Development Strategy for the Investigational Aurora A Kinase Inhibitor Alisertib in CancerAdvances in targeted therapies and new promising targets in esophageal cancerAurora kinase A in gastrointestinal cancers: time to targetPrognostic value of Aurora kinase A (AURKA) expression among solid tumor patients: a systematic review and meta-analysisCIViC databaseAurora-A contributes to cisplatin resistance and lymphatic metastasis in non-small cell lung cancer and predicts poor prognosisAurora kinases as targets in drug-resistant neuroblastoma cellsPhase I study of the aurora A kinase inhibitor alisertib with induction chemotherapy in patients with acute myeloid leukemia.Dual Aurora A and JAK2 kinase blockade effectively suppresses malignant transformation.The Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidyTargeting Aurora kinase-A downregulates cell proliferation and angiogenesis in neuroblastoma.AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers.Issues in interpreting the in vivo activity of Aurora-AInhibition of mitotic Aurora kinase A by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI-N78 cells.Suppression of Aurora-A-FLJ10540 signaling axis prohibits the malignant state of head and neck cancerThe role of Dickkopf-3 overexpression in esophageal adenocarcinomaInhibition of the Aurora A kinase augments the anti-tumor efficacy of oncolytic measles virotherapy.Targeting Aurora A kinase activity with the investigational agent alisertib increases the efficacy of cytarabine through a FOXO-dependent mechanism.A novel intraperitoneal metastatic xenograft mouse model for survival outcome assessment of esophageal adenocarcinomaThe combination of alisertib, an investigational Aurora kinase A inhibitor, and docetaxel promotes cell death and reduces tumor growth in preclinical cell models of upper gastrointestinal adenocarcinomas.Alisertib Induces Cell Cycle Arrest, Apoptosis, Autophagy and Suppresses EMT in HT29 and Caco-2 Cells.In silico discovery of mitosis regulation networks associated with early distant metastases in estrogen receptor positive breast cancers.The investigational Aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo.APE1-mediated DNA damage repair provides survival advantage for esophageal adenocarcinoma cells in response to acidic bile salts.Aurora kinase A promotes inflammation and tumorigenesis in mice and human gastric neoplasia.Ras-driven transcriptome analysis identifies aurora kinase A as a potential malignant peripheral nerve sheath tumor therapeutic target.Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer.HDM2 regulation by AURKA promotes cell survival in gastric cancer.Cell cycle proteins as promising targets in cancer therapyAurora-A is a determinant of tamoxifen sensitivity through phosphorylation of ERα in breast cancer.Aurora-A: a potential DNA repair modulator.Emerging kinase inhibitors of the treatment of gastric cancer.An update on the pharmacokinetics and pharmacodynamics of alisertib, a selective Aurora kinase A inhibitor.Characterization of Aurora A and Its Impact on the Effect of Cisplatin-Based Chemotherapy in Patients with Non-Small Cell Lung Cancer.Cisplatin-resistant cancer cells are sensitive to Aurora kinase A inhibition by alisertib.Aurora-A Kinase: A Potent Oncogene and Target for Cancer Therapy.Characterization of a novel tumorigenic esophageal adenocarcinoma cell line: OANC1.Molecular pathways: induction of polyploidy as a novel differentiation therapy for leukemia.AURKA suppression induces DU145 apoptosis and sensitizes DU145 to docetaxel treatment.
P2860
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P2860
The aurora kinase A inhibitor MLN8237 enhances cisplatin-induced cell death in esophageal adenocarcinoma cells
description
2012 nî lūn-bûn
@nan
2012 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մարտին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
The aurora kinase A inhibitor ...... sophageal adenocarcinoma cells
@ast
The aurora kinase A inhibitor ...... sophageal adenocarcinoma cells
@en
The aurora kinase A inhibitor ...... ophageal adenocarcinoma cells.
@nl
type
label
The aurora kinase A inhibitor ...... sophageal adenocarcinoma cells
@ast
The aurora kinase A inhibitor ...... sophageal adenocarcinoma cells
@en
The aurora kinase A inhibitor ...... ophageal adenocarcinoma cells.
@nl
altLabel
The aurora kinase A inhibitor ...... sophageal adenocarcinoma cells
@en
prefLabel
The aurora kinase A inhibitor ...... sophageal adenocarcinoma cells
@ast
The aurora kinase A inhibitor ...... sophageal adenocarcinoma cells
@en
The aurora kinase A inhibitor ...... ophageal adenocarcinoma cells.
@nl
P2093
P2860
P3181
P1476
The aurora kinase A inhibitor ...... sophageal adenocarcinoma cells
@en
P2093
Abbes Belkhiri
Alexander Zaika
DunFa Peng
Frank Revetta
Jeffrey Ecsedy
M Kay Washington
Mohammed Soutto
Regine Schneider-Stock
Tilman T Rau
Vikas Sehdev
P2860
P304
P3181
P356
10.1158/1535-7163.MCT-11-0623
P407
P577
2012-03-01T00:00:00Z