Phenotypic alterations in insulin-deficient mutant mice.
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Endothelium-derived essential signals involved in pancreas organogenesisTwo membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signalingDisruption of the Golgi protein Otg1 gene causes defective hormone secretion and aberrant glucose homeostasis in mice.Development of a Rapid Insulin Assay by Homogenous Time-Resolved Fluorescencepdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasisInsulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesisGlucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survivalIGF-1 receptor as an alternative receptor for metabolic signaling in insulin receptor-deficient muscle cells.Cdkn1c (p57Kip2) is the major regulator of embryonic growth within its imprinted domain on mouse distal chromosome 7.Postnatal survival of mice with maternal duplication of distal chromosome 7 induced by a Igf2/H19 imprinting control region lacking insulator functionAcute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathwaysTargeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development.Drosophila as a Model for Diabetes and Diseases of Insulin Resistance.Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis.Conditional knockout of mouse insulin-like growth factor-1 gene using the Cre/loxP system.Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription.Saturation of the human phenomePancreatic development and adult diabetes.Genetic manipulation of insulin signaling, action and secretion in mice. Insights into glucose homeostasis and pathogenesis of type 2 diabetes.The use of animal models in diabetes research.Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.Genetic engineering in mice: impact on insulin signalling and action.Defined culture conditions of human embryonic stem cells.Thymus-specific deletion of insulin induces autoimmune diabetes.Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD miceOrgan-specific defects in insulin-like growth factor and insulin receptor signaling in late gestational asymmetric intrauterine growth restriction in Cited1 mutant miceApoptosis in the beta cells: cause or consequence of insulin secretion defect in diabetes?Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes.Lifespan and glucose metabolism in insulin receptor mutant mice.Ribosomal protein mutations induce autophagy through S6 kinase inhibition of the insulin pathway.A practical guide to genetic engineering of pancreatic β-cells in vivo: getting a grip on RIP and MIP.Central and peripheral autoantigen presentation in immune tolerance.Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity.Hyper-Variability in Circulating Insulin, High Fat Feeding Outcomes, and Effects of Reducing Ins2 Dosage in Male Ins1-Null Mice in a Specific Pathogen-Free Facility.Insulin rescues impaired spermatogenesis via the hypothalamic-pituitary-gonadal axis in Akita diabetic mice and restores male fertilitySuppression of hyperinsulinaemia in growing female mice provides long-term protection against obesity.The stages of type 1A diabetes: 2005.Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation.Epigenetic and phenotypic consequences of a truncation disrupting the imprinted domain on distal mouse chromosome 7.Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis.
P2860
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P2860
Phenotypic alterations in insulin-deficient mutant mice.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Phenotypic alterations in insulin-deficient mutant mice.
@ast
Phenotypic alterations in insulin-deficient mutant mice.
@en
type
label
Phenotypic alterations in insulin-deficient mutant mice.
@ast
Phenotypic alterations in insulin-deficient mutant mice.
@en
prefLabel
Phenotypic alterations in insulin-deficient mutant mice.
@ast
Phenotypic alterations in insulin-deficient mutant mice.
@en
P2093
P2860
P356
P1476
Phenotypic alterations in insulin-deficient mutant mice
@en
P2093
D Bucchini
E Monthioux
F Dandoy-Dron
N Cordonnier
P2860
P304
P356
10.1073/PNAS.94.10.5137
P407
P577
1997-05-01T00:00:00Z