A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.
about
FAK and paxillin, two potential targets in pancreatic cancerMechanistic evaluation of a novel small molecule targeting mitochondria in pancreatic cancer cellsEvolving Therapies and FAK Inhibitors for the Treatment of CancerInterleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1.Pancreatic stellate cells promote hapto-migration of cancer cells through collagen I-mediated signalling pathway.A simple knowledge-based mining method for exploring hidden key molecules in a human biomolecular network.Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastomaPND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells.High focal adhesion kinase expression in breast carcinoma is associated with lymphovascular invasion and triple-negative phenotype.Focal adhesion kinase antagonizes doxorubicin cardiotoxicity via p21(Cip1.).Focal adhesion remodeling is crucial for glucose-stimulated insulin secretion and involves activation of focal adhesion kinase and paxillin.Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insightsA novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenograftsEpidermal growth factor-induced cyclooxygenase-2 enhances head and neck squamous cell carcinoma metastasis through fibronectin up-regulationIdentification of FAK substrate peptides via colorimetric screening of a one-bead one-peptide combinatorial library.Targeting focal adhesion kinase in neuroblastoma.Novel mechanistic link between focal adhesion remodeling and glucose-stimulated insulin secretionNanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated.Targeting Focal Adhesion Kinase and Resistance to mTOR Inhibition in Pancreatic Neuroendocrine TumorsCombination of heat shock protein 90 and focal adhesion kinase inhibitors synergistically inhibits the growth of non-small cell lung cancer cells.Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death.Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth.3'3-Diindolylmethane inhibits migration, invasion and metastasis of hepatocellular carcinoma by suppressing FAK signaling.Focal adhesion kinase overexpression and its impact on human osteosarcoma.Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide.FAK Inhibition Decreases Hepatoblastoma Survival Both In Vitro and In Vivo.Mitoxantrone targets the ATP-binding site of FAK, binds the FAK kinase domain and decreases FAK, Pyk-2, c-Src, and IGF-1R in vitro kinase activitiesTargeting Focal Adhesion Kinase Suppresses the Malignant Phenotype in Rhabdomyosarcoma CellsTargeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy.Efficacy of focal adhesion kinase inhibition in non-small cell lung cancer with oncogenically activated MAPK pathways.Targeting the p53 pathway.Focal adhesion kinase autophosphorylation inhibition decreases colon cancer cell growth and enhances the efficacy of chemotherapy.The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth.MiR-138 and MiR-135 directly target focal adhesion kinase, inhibit cell invasion, and increase sensitivity to chemotherapy in cancer cells.Aurora kinase A revives dormant laryngeal squamous cell carcinoma cells via FAK/PI3K/Akt pathway activation.FAK inhibition abrogates the malignant phenotype in aggressive pediatric renal tumorsTherapeutic potential and limitations of new FAK inhibitors in the treatment of cancer.Focal adhesion kinase as a cancer therapy target.FAK and Nanog cross talk with p53 in cancer stem cells.
P2860
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P2860
A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.
@ast
A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.
@en
type
label
A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.
@ast
A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.
@en
prefLabel
A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.
@ast
A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.
@en
P2093
P2860
P356
P1433
P1476
A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer
@en
P2093
Carl Nyberg
Cheng Wood
David Ostrov
Donghang Zheng
Nicole A Massoll
Steven N Hochwald
Vita M Golubovskaya
William G Cance
P2860
P304
P356
10.4161/CC.8.15.9145
P577
2009-08-01T00:00:00Z