Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects. - Wikidata - awgldk - TriplyDB

Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects.

Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects.

http://www.wikidata.org/entity/Q36778228

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Current use of medical eponyms--a need for global uniformity in scientific publications Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes Modifications of the endosomal compartment in peripheral blood mononuclear cells and fibroblasts from Alzheimer's disease patients In vitro intracellular trafficking of virulence antigen during infection by Yersinia pestis.Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression.Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.Endosomal Nox2 facilitates redox-dependent induction of NF-kappaB by TNF-alpha.Electrophysiology of reactive oxygen production in signaling endosomes A novel binding protein of single-minded 2: the mitotic arrest-deficient protein MAD2B.Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits Regional selectivity of rab5 and rab7 protein upregulation in mild cognitive impairment and Alzheimer's disease Dysregulation of protein trafficking in neurodegeneration.Multivesicular bodies in neurons: distribution, protein content, and trafficking functions.Autophagy failure in Alzheimer's disease--locating the primary defect.The Na+/H+ exchanger NHE6 modulates endosomal pH to control processing of amyloid precursor protein in a cell culture model of Alzheimer disease.Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease.Comparative lipidomic analysis of mouse and human brain with Alzheimer disease.Age-related neurodegeneration and memory loss in down syndrome.Strain-Specific Altered Regulatory Response of Rab7a and Tau in Creutzfeldt-Jakob Disease and Alzheimer's Disease.The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease.Alzheimer's disease in a dish: promises and challenges of human stem cell models.Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease.Brief report: isogenic induced pluripotent stem cell lines from an adult with mosaic down syndrome model accelerated neuronal ageing and neurodegeneration.Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF.Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21.Early endosomal abnormalities and cholinergic neuron degeneration in amyloid-β protein precursor transgenic mice.Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome.Dynein dysfunction induces endocytic pathology accompanied by an increase in Rab GTPases: a potential mechanism underlying age-dependent endocytic dysfunction Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain.The early endosome: a busy sorting station for proteins at the crossroads.Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositides.Frontotemporal dementia caused by CHMP2B mutations.Mammalian target of rapamycin: a valid therapeutic target through the autophagy pathway for Alzheimer's disease?Lysosomal fusion dysfunction as a unifying hypothesis for Alzheimer's disease pathology.Aging and intellectual disability: insights from mouse models of Down syndrome.Intersectin-1s: an important regulator of cellular and molecular pathways in lung injury.Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities.Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells.

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Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects.

http://www.wikidata.org/entity/Q36778228

description

2008 nî lūn-bûn

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2008年论文

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Down syndrome fibroblast model ...... omotes late endocytic defects.

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Down syndrome fibroblast model ...... omotes late endocytic defects.

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Down syndrome fibroblast model ...... omotes late endocytic defects.

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The American Journal of Pathology

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Down syndrome fibroblast model ...... omotes late endocytic defects.

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Anne Boyer Boiteau

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Anne M Cataldo

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Corrinne M Peterhoff

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Jean Gruenberg

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Kerry Mullaney

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Linda C Hassinger

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Rachael L Neve

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Ralph A Nixon

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Ying Jiang

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P2860

Direct interaction of EEA1 with Rab5b

Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

The rab7 GTPase resides on a vesicular compartment connected to lysosomes

Characterization of the endosomal sorting signal of the cation-dependent mannose 6-phosphate receptor

Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger

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18535180

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Alzheimer's disease

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