Redundant control of adenovirus late gene expression by early region 4
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Interaction of the adenovirus type 5 E4 Orf3 protein with promyelocytic leukemia protein isoform II is required for ND10 disruption.Induction of endogenous genes following infection of human endothelial cells with an E1(-) E4(+) adenovirus gene transfer vectorTransduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesisThe Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage ResponseAnalysis of human cytomegalovirus oriLyt sequence requirements in the context of the viral genome.Adenovirus core protein VII protects the viral genome from a DNA damage response at early times after infection.Transforming potential of the adenovirus type 5 E4orf3 protein.Roles for the E4 orf6, orf3, and E1B 55-kilodalton proteins in cell cycle-independent adenovirus replication.Relocalization of the Mre11-Rad50-Nbs1 complex by the adenovirus E4 ORF3 protein is required for viral replicationIn vitro and in vivo biology of recombinant adenovirus vectors with E1, E1/E2A, or E1/E4 deleted.The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis.Adenovirus late gene expression does not require a Rev-like nuclear RNA export pathway.An arginine-faced amphipathic alpha helix is required for adenovirus type 5 e4orf6 protein functionGeneration of an adenovirus vector lacking E1, e2a, E3, and all of E4 except open reading frame 3.Regulation of adenovirus-mediated transgene expression by the viral E4 gene products: requirement for E4 ORF3.A functional complex of adenovirus proteins E1B-55kDa and E4orf6 is necessary to modulate the expression level of p53 but not its transcriptional activity.Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complexAdenovirus early region 4 stimulates mRNA accumulation via 5' introns.Adenoviral vectors can impair adrenocortical steroidogenesis: clinical implications for natural infections and gene therapyNucleotide sequence, genome organization, and transcription map of bovine adenovirus type 3.Adenovirus E1B 55-kilodalton protein is a p53-SUMO1 E3 ligase that represses p53 and stimulates its nuclear export through interactions with promyelocytic leukemia nuclear bodies.Expression of the adenovirus E4 34k oncoprotein inhibits repair of double strand breaks in the cellular genome of a 293-based inducible cell line.E4orf6 variants with separate abilities to augment adenovirus replication and direct nuclear localization of the E1B 55-kilodalton protein.Genetic identification of adenovirus type 5 genes that influence viral spread.The human adenovirus type 5 E1B 55 kDa protein obstructs inhibition of viral replication by type I interferon in normal human cells.Extrachromosomal recombination occurs efficiently in cells defective in various DNA repair systemsDistinct roles of the Adenovirus E4 ORF3 protein in viral DNA replication and inhibition of genome concatenation.Effects of the deletion of early region 4 (E4) open reading frame 1 (orf1), orf1-2, orf1-3 and orf1-4 on virus-host cell interaction, transgene expression, and immunogenicity of replicating adenovirus HIV vaccine vectors.An activity associated with human chromosome 21 permits nuclear colocalization of the adenovirus E1B-55K and E4orf6 proteins and promotes viral late gene expression.The adenovirus E4 11 k protein binds and relocalizes the cytoplasmic P-body component Ddx6 to aggresomes.E4orf3 is necessary for enhanced S-phase replication of cell cycle-restricted subgroup C adenovirusesComplementation of adenovirus E4 mutants by transient expression of E4 cDNA and deletion plasmids.Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit.Human adenovirus type 9 E4 open reading frame 1 encodes a cytoplasmic transforming protein capable of increasing the oncogenicity of CREF cellsAdenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosisAdenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells.Human adenovirus early region 4 open reading frame 1 genes encode growth-transforming proteins that may be distantly related to dUTP pyrophosphatase enzymes.Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells.A carboxy-terminal region required by the adenovirus type 9 E4 ORF1 oncoprotein for transformation mediates direct binding to cellular polypeptides.Role of the RNA recognition motif of the E1B 55 kDa protein in the adenovirus type 5 infectious cycle.
P2860
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P2860
Redundant control of adenovirus late gene expression by early region 4
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
Redundant control of adenovirus late gene expression by early region 4
@ast
Redundant control of adenovirus late gene expression by early region 4
@en
type
label
Redundant control of adenovirus late gene expression by early region 4
@ast
Redundant control of adenovirus late gene expression by early region 4
@en
prefLabel
Redundant control of adenovirus late gene expression by early region 4
@ast
Redundant control of adenovirus late gene expression by early region 4
@en
P2860
P1433
P1476
Redundant control of adenovirus late gene expression by early region 4
@en
P2093
P2860
P304
P407
P577
1989-02-01T00:00:00Z