Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis
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Regulation of apoptosis by viral gene productsMechanisms of cancer cell killing by the adenovirus E4orf4 proteinThe Human Adenovirus Type 5 E4orf4 Protein Targets Two Phosphatase Regulators of the Hippo Signaling PathwayCytoplasmic death signal triggered by SRC-mediated phosphorylation of the adenovirus E4orf4 protein.Analysis by live imaging of effects of the adenovirus E4orf4 protein on passage through mitosis of H1299 tumor cells.The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis.Induction of p53-independent apoptosis by the adenovirus E4orf4 protein requires binding to the Balpha subunit of protein phosphatase 2A.Bax-mediated cell death by the Gax homeoprotein requires mitogen activation but is independent of cell cycle activityGenetic analysis of B55alpha/Cdc55 protein phosphatase 2A subunits: association with the adenovirus E4orf4 protein.Interaction of adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression.Accumulation of p53 induced by the adenovirus E1A protein requires regions involved in the stimulation of DNA synthesis.Phosphorylation within the transactivation domain of adenovirus E1A protein by mitogen-activated protein kinase regulates expression of early region 4Regulation of p53-dependent apoptosis, transcriptional repression, and cell transformation by phosphorylation of the 55-kilodalton E1B protein of human adenovirus type 5.Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells.Identification of a novel antiapoptotic functional domain in simian virus 40 large T antigen.E4orf4, a novel adenovirus death factor that induces p53-independent apoptosis by a pathway that is not inhibited by zVAD-fmkSpecific isoforms of p73 control the induction of cell death induced by the viral proteins, E1A or apoptinThe adenoviral E1B 55-kilodalton protein controls expression of immune response genes but not p53-dependent transcription.The adenovirus E4orf4 protein induces G2/M arrest and cell death by blocking protein phosphatase 2A activity regulated by the B55 subunit.Oncolytic viruses & their specific targeting to tumour cells.Identification of the adenovirus E4orf4 protein binding site on the B55α and Cdc55 regulatory subunits of PP2A: Implications for PP2A function, tumor cell killing and viral replication.Adenovirus E4orf4 protein-induced death of p53-/- H1299 human cancer cells follows a G1 arrest of both tetraploid and diploid cells due to a failure to initiate DNA synthesis.Hepatitis C virus core protein induces apoptosis-like caspase independent cell death.The replicative capacities of large E1B-null group A and group C adenoviruses are independent of host cell p53 statusAdenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells.Role of the Fas/Fas ligand apoptotic pathway in human immunodeficiency virus type 1 diseaseEffect of the E4 region on the persistence of transgene expression from adenovirus vectors.Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo.Conditionally replicating adenoviruses kill tumor cells via a basic apoptotic machinery-independent mechanism that resembles necrosis-like programmed cell death.Characterization of the recombinant adenovirus vector AdYB-1: implications for oncolytic vector development.
P2860
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P2860
Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis
@ast
Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis
@en
type
label
Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis
@ast
Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis
@en
prefLabel
Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis
@ast
Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis
@en
P2093
P2860
P1433
P1476
Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis
@en
P2093
Branton PE
Marcellus RC
Teodoro JG
P2860
P304
P407
P577
1996-09-01T00:00:00Z