Membrane heterogeneities in the formation of B cell receptor-Lyn kinase microclusters and the immune synapse.
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Understanding the initiation of B cell signaling through live cell imaging.FcRL4 acts as an adaptive to innate molecular switch dampening BCR signaling and enhancing TLR signaling.The constant region of the membrane immunoglobulin mediates B cell-receptor clustering and signaling in response to membrane antigens.T-cell receptor microclusters critical for T-cell activation are formed independently of lipid raft clusteringIntrinsic properties of immunoglobulin IgG1 isotype-switched B cell receptors promote microclustering and the initiation of signalingAntigen-induced oligomerization of the B cell receptor is an early target of Fc gamma RIIB inhibition.A balance of Bruton's tyrosine kinase and SHIP activation regulates B cell receptor cluster formation by controlling actin remodeling.Intrinsic differences in the initiation of B cell receptor signaling favor responses of human IgG(+) memory B cells over IgM(+) naive B cells.Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity.Steady-state cross-correlations for live two-colour super-resolution localization data sets.No receptor stands alone: IgG B-cell receptor intrinsic and extrinsic mechanisms contribute to antibody memoryAntigen affinity discrimination is an intrinsic function of the B cell receptor.Actin-binding protein 1 links B-cell antigen receptors to negative signaling pathwaysIt's all about change: the antigen-driven initiation of B-cell receptor signalingDistribution and dynamics of rat basophilic leukemia immunoglobulin E receptors (FcepsilonRI) on planar ligand-presenting surfaces.Encoding immunological memory in the initiation of B-cell receptor signalingMaternal immunization with ovalbumin or Dermatophagoides pteronyssinus has opposing effects on FcγRIIb expression on offspring B cellsActivation of Lyn tyrosine kinase through decreased membrane cholesterol levels during a change in its membrane distribution upon cell detachment.Microdomains in the membrane landscape shape antigen-presenting cell function.Uniform total internal reflection fluorescence illumination enables live cell fluorescence resonance energy transfer microscopy.Lipid raft-based membrane order is important for antigen-specific clonal expansion of CD4(+) T lymphocytes.N-wasp is essential for the negative regulation of B cell receptor signaling.Systems biology in immunology: a computational modeling perspective.Actin reorganization is required for the formation of polarized B cell receptor signalosomes in response to both soluble and membrane-associated antigens.A computational model for early events in B cell antigen receptor signaling: analysis of the roles of Lyn and Fyn.A conformation-induced oligomerization model for B cell receptor microclustering and signalingImaging techniques for assaying lymphocyte activation in action.The tipping points in the initiation of B cell signalling: how small changes make big differences.A method for analyzing protein-protein interactions in the plasma membrane of live B cells by fluorescence resonance energy transfer imaging as acquired by total internal reflection fluorescence microscopy.The scaffolding protein synapse-associated protein 97 is required for enhanced signaling through isotype-switched IgG memory B cell receptors.LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.Lipid raft-dependent plasma membrane repair interferes with the activation of B lymphocytesCD23 can negatively regulate B-cell receptor signaling.Formation of BCR oligomers provides a mechanism for B cell affinity discrimination.Discrimination of membrane antigen affinity by B cells requires dominance of kinetic proofreading over serial engagement.Activation of the B cell receptor leads to increased membrane proximity of the Igα cytoplasmic domainUnderstanding B cell activation: from single molecule tracking, through Tolls, to stalking memory in malariaThe nanoscale spatial organization of B-cell receptors on immunoglobulin M- and G-expressing human B-cells.Induction and regulation of Trypanosoma brucei VSG-specific antibody responses.Protein sorting by lipid phase-like domains supports emergent signaling function in B lymphocyte plasma membranes.
P2860
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P2860
Membrane heterogeneities in the formation of B cell receptor-Lyn kinase microclusters and the immune synapse.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Membrane heterogeneities in th ...... usters and the immune synapse.
@ast
Membrane heterogeneities in th ...... usters and the immune synapse.
@en
type
label
Membrane heterogeneities in th ...... usters and the immune synapse.
@ast
Membrane heterogeneities in th ...... usters and the immune synapse.
@en
prefLabel
Membrane heterogeneities in th ...... usters and the immune synapse.
@ast
Membrane heterogeneities in th ...... usters and the immune synapse.
@en
P2093
P2860
P356
P1476
Membrane heterogeneities in th ...... usters and the immune synapse.
@en
P2093
Hae Won Sohn
Pavel Tolar
Susan K Pierce
P2860
P304
P356
10.1083/JCB.200802007
P407
P577
2008-07-21T00:00:00Z