Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury
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Chemical probes of endocannabinoid metabolismPerformance of Male and Female C57BL/6J Mice on Motor and Cognitive Tasks Commonly Used in Pre-Clinical Traumatic Brain Injury ResearchDifferential Expression of Brain Cannabinoid Receptors between Repeatedly Stressed Males and Females may Play a Role in Age and Gender-Related Difference in Traumatic Brain Injury: Implications from Animal Studies.Microglial Activation in Traumatic Brain Injury.Endocannabinoids in synaptic plasticity and neuroprotection.Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites.Lupus risk variants in the PXK locus alter B-cell receptor internalization.Endocannabinoid degradation inhibition improves neurobehavioral function, blood-brain barrier integrity, and neuroinflammation following mild traumatic brain injury.Inhibition of monoacylglycerol lipase prevents chronic traumatic encephalopathy-like neuropathology in a mouse model of repetitive mild closed head injury.Organic carbamates in drug design and medicinal chemistryThe fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury.Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors.Microglia in the TBI brain: The good, the bad, and the dysregulated.α/β-Hydrolase domain-containing 6 (ABHD6) negatively regulates the surface delivery and synaptic function of AMPA receptors.Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitorsTGFβ1 exacerbates blood-brain barrier permeability in a mouse model of hepatic encephalopathy via upregulation of MMP9 and downregulation of claudin-5WWL70 attenuates PGE2 production derived from 2-arachidonoylglycerol in microglia by ABHD6-independent mechanism.Endocannabinoids: A Promising Impact for Traumatic Brain Injury.Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6)Endocannabinoids and neuropathic pain: focus on neuron-glia and endocannabinoid-neurotrophin interactions.Functions of the CB1 and CB 2 receptors in neuroprotection at the level of the blood-brain barrier.Endocannabinoids, related compounds and their metabolic routes.Cannabinoids in Neurodegenerative Disorders and Stroke/Brain Trauma: From Preclinical Models to Clinical Applications.Chemical Genetic Approaches for the Investigation of Neutral Lipid Metabolism.α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate.Investigation of left and right lateral fluid percussion injury in C57BL6/J mice: In vivo functional consequences.Monoacylglycerol signalling and ABHD6 in health and disease.WWL70 protects against chronic constriction injury-induced neuropathic pain in mice by cannabinoid receptor-independent mechanisms.Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury.
P2860
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P2860
Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown, and improves functional recovery in a mouse model of traumatic brain injury
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Selective inhibition of alpha/ ...... odel of traumatic brain injury
@en
type
label
Selective inhibition of alpha/ ...... odel of traumatic brain injury
@en
prefLabel
Selective inhibition of alpha/ ...... odel of traumatic brain injury
@en
P2860
P356
P1476
Selective inhibition of alpha/ ...... odel of traumatic brain injury
@en
P2093
Flaubert Tchantchou
Yumin Zhang
P2860
P304
P356
10.1089/NEU.2012.2647
P577
2013-04-05T00:00:00Z