Critical role of the central 139-loop in stability and binding selectivity of arrestin-1.
about
A Novel Dominant Mutation in SAG, the Arrestin-1 Gene, Is a Common Cause of Retinitis Pigmentosa in Hispanic Families in the Southwestern United States.Identification of receptor binding-induced conformational changes in non-visual arrestins.C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptorGPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014.Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 bindingFunctional map of arrestin-1 at single amino acid resolutionExtensive shape shifting underlies functional versatility of arrestins.Beyond traditional pharmacology: new tools and approaches.Structural mechanism of GPCR-arrestin interaction: recent breakthroughs.Structural evidence for the role of polar core residue Arg175 in arrestin activation.Targeting individual GPCRs with redesigned nonvisual arrestins.Arrestin-3 binds the MAP kinase JNK3α2 via multiple sites on both domains.Rapid degeneration of rod photoreceptors expressing self-association-deficient arrestin-1 mutant.Therapeutic potential of small molecules and engineered proteins.Arrestin-dependent activation of JNK family kinasesEnhanced phosphorylation-independent arrestins and gene therapy.The rhodopsin-arrestin-1 interaction in bicelles.Differential manipulation of arrestin-3 binding to basal and agonist-activated G protein-coupled receptors.Arrestin expression in E. coli and purification.Molecular Defects of the Disease-Causing Human Arrestin-1 C147F Mutant.Molecular Mechanisms of GPCR Signaling: A Structural Perspective.Functional role of the three conserved cysteines in the N domain of visual arrestin-1.
P2860
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P2860
Critical role of the central 139-loop in stability and binding selectivity of arrestin-1.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Critical role of the central 139-loop in stability and binding selectivity of arrestin-1.
@en
type
label
Critical role of the central 139-loop in stability and binding selectivity of arrestin-1.
@en
prefLabel
Critical role of the central 139-loop in stability and binding selectivity of arrestin-1.
@en
P2093
P2860
P356
P1476
Critical role of the central 139-loop in stability and binding selectivity of arrestin-1
@en
P2093
Faiza Baameur
Kristen R Findley
Sergey A Vishnivetskiy
P2860
P304
11741-11750
P356
10.1074/JBC.M113.450031
P407
P577
2013-03-08T00:00:00Z