Avian reticuloendotheliosis virus-transformed lymphoid cells contain multiple pp59v-rel complexes.
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Mutational analysis of the v-Rel dimerization interface reveals a critical role for v-Rel homodimers in transformationI kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motifThe NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa BThe RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoproteinThe p50 subunit of NF-kappa B associates with the NF-IL6 transcription factor.Loss of IkappaB alpha-mediated control over nuclear import and DNA binding enables oncogenic activation of c-RelHormone-regulated v-rel estrogen receptor fusion protein: reversible induction of cell transformation and cellular gene expressionAlternative splicing of RNA transcripts encoded by the murine p105 NF-kappa B gene generates I kappa B gamma isoforms with different inhibitory activities.The relocalization of v-Rel from the nucleus to the cytoplasm coincides with induction of expression of Ikba and nfkb1 and stabilization of I kappa B-alpha.Constitutive and inducible kappa B binding activities in the cytosol of v-Rel-transformed lymphoid cells.Avian I kappa B alpha is transcriptionally induced by c-Rel and v-Rel with different kineticsMultiple mechanisms are implicated in the regulation of NF-kappa B activity during human cytomegalovirus infection.Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alphav-rel Induces ectopic expression of an adhesion molecule, DM-GRASP, during B-lymphoma developmentInteraction of the v-Rel oncoprotein with NF-kappaB and IkappaB proteins: heterodimers of a transformation-defective v-Rel mutant and NF-2 are functional in vitro and in vivo.v-rel induces expression of three avian immunoregulatory surface receptors more efficiently than c-rel.Evolution of the oncogenic potential of v-rel: rel-induced expression of immunoregulatory receptors correlates with tumor development and in vitro transformationTransformation of avian fibroblasts overexpressing the c-rel proto-oncogene and a variant of c-rel lacking 40 C-terminal amino acids.In vivo evolution of c-rel oncogenic potential.Heterologous C-terminal sequences disrupt transcriptional activation and oncogenesis by p59v-rel.NF-kappa B p100 is one of the high-molecular-weight proteins complexed with the v-Rel oncoprotein in transformed chicken spleen cells.Differential pp40I kappa B-beta inhibition of DNA binding by rel proteinsvRel is an inactive member of the Rel family of transcriptional activating proteins.p105, the NF-kappa B p50 precursor protein, is one of the cellular proteins complexed with the v-Rel oncoprotein in transformed chicken spleen cells.Kappa B site-dependent activation of the interleukin-2 receptor alpha-chain gene promoter by human c-RelThe mouse c-rel protein has an N-terminal regulatory domain and a C-terminal transcriptional transactivation domain.Rapid induction in regenerating liver of RL/IF-1 (an I kappa B that inhibits NF-kappa B, RelB-p50, and c-Rel-p50) and PHF, a novel kappa B site-binding complex.Identification of a rel-related protein in the nucleus during the S phase of the cell cycle.c-rel activates but v-rel suppresses transcription from kappa B sites.Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family.The v-rel oncogene promotes malignant T-cell leukemia/lymphoma in transgenic mice.Bcl-3 expression promotes cell survival following interleukin-4 deprivation and is controlled by AP1 and AP1-like transcription factors.NF-kappa B/Rel family members are physically associated phosphoproteins.Diverse molecular mechanisms of inhibition of NF-kappa B/DNA binding complexes by I kappa B proteins
P2860
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P2860
Avian reticuloendotheliosis virus-transformed lymphoid cells contain multiple pp59v-rel complexes.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Avian reticuloendotheliosis vi ...... multiple pp59v-rel complexes.
@ast
Avian reticuloendotheliosis vi ...... multiple pp59v-rel complexes.
@en
type
label
Avian reticuloendotheliosis vi ...... multiple pp59v-rel complexes.
@ast
Avian reticuloendotheliosis vi ...... multiple pp59v-rel complexes.
@en
prefLabel
Avian reticuloendotheliosis vi ...... multiple pp59v-rel complexes.
@ast
Avian reticuloendotheliosis vi ...... multiple pp59v-rel complexes.
@en
P2093
P2860
P1433
P1476
Avian reticuloendotheliosis vi ...... multiple pp59v-rel complexes.
@en
P2093
P2860
P304
P407
P577
1990-02-01T00:00:00Z