The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein
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A novel NF-kappa B complex containing p65 homodimers: implications for transcriptional control at the level of subunit dimerizationA novel DNA recognition mode by the NF-kappa B p65 homodimerThe sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolismMutational analysis of the v-Rel dimerization interface reveals a critical role for v-Rel homodimers in transformationStructural requirements for DNA binding of GCM proteinsI kappa B alpha-mediated inhibition of v-Rel DNA binding requires direct interaction with the RXXRXRXXC Rel/kappa B DNA-binding motifCooperative DNA binding of the human HoxB5 (Hox-2.1) protein is under redox regulation in vitroRegulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-kappa B/Rel transcription factorsEthyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skinRegulation of cell survival and death by pyridine nucleotidesTwo alleles of NF-kappaB in the sea anemone Nematostella vectensis are widely dispersed in nature and encode proteins with distinct activitiesCyclopentenone prostaglandins: new insights on biological activities and cellular targetsDNA binding alters the protease susceptibility of the p50 subunit of NF-kappa B.Methylglyoxal alters the function and stability of critical components of the protein quality control.AP-1 factors play an important role in transformation induced by the v-rel oncogene.Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel.Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), inhibit activation of nuclear factor-kappaB by inhibiting both its nuclear localization and ability to bind DNAMapping of a serine-rich domain essential for the transcriptional, antiapoptotic, and transforming activities of the v-Rel oncoprotein.Inhibition of AP-1 binding and transcription by gold and selenium involving conserved cysteine residues in Jun and Fos.Mutations in the v-Rel transactivation domain indicate altered phosphorylation and identify a subset of NF-kappaB-regulated cell death inhibitors important for v-Rel transforming activity.The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domainsDispensable role of the NF-kappa B sites in the UV-induction of the HIV-1 LTR in transgenic mice.Oncogenic conversion of Ets affects redox regulation in-vivo and in-vitro.Time and Demand are Two Critical Dimensions of Immunometabolism: The Process of Macrophage Activation and the Pentose Phosphate Pathway.15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway.Mutations in the DNA-binding and dimerization domains of v-Rel are responsible for altered kappa B DNA-binding complexes in transformed cellsThe immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB.The PEST-like sequence of I kappa B alpha is responsible for inhibition of DNA binding but not for cytoplasmic retention of c-Rel or RelA homodimers.Evolution of the oncogenic potential of v-rel: rel-induced expression of immunoregulatory receptors correlates with tumor development and in vitro transformationTransformation of avian fibroblasts overexpressing the c-rel proto-oncogene and a variant of c-rel lacking 40 C-terminal amino acids.In vivo evolution of c-rel oncogenic potential.Temperature-sensitive transforming mutants of the v-rel oncogene.N-terminal DNA-binding domains contribute to differential DNA-binding specificities of NF-kappa B p50 and p65.An interaction between the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activationPosttranscriptional down-regulation of ras oncogene expression by inhibitors of cellular glutathione.Functional interaction of the v-Rel and c-Rel oncoproteins with the TATA-binding protein and association with transcription factor IIB.Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNFα/NF-κB response.CAPERalpha is a novel Rel-TAD-interacting factor that inhibits lymphocyte transformation by the potent Rel/NF-kappaB oncoprotein v-Rel.Caspase-3-mediated cleavage of p65/RelA results in a carboxy-terminal fragment that inhibits IkappaBalpha and enhances HIV-1 replication in human T lymphocytes.Evidence for a non-alpha-helical DNA-binding motif in the Rel homology region.
P2860
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P2860
The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein
description
1992 nî lūn-bûn
@nan
1992 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
The RxxRxRxxC motif conserved ...... ation of the v-Rel oncoprotein
@ast
The RxxRxRxxC motif conserved ...... ation of the v-Rel oncoprotein
@en
The RxxRxRxxC motif conserved ...... ation of the v-Rel oncoprotein
@nl
type
label
The RxxRxRxxC motif conserved ...... ation of the v-Rel oncoprotein
@ast
The RxxRxRxxC motif conserved ...... ation of the v-Rel oncoprotein
@en
The RxxRxRxxC motif conserved ...... ation of the v-Rel oncoprotein
@nl
prefLabel
The RxxRxRxxC motif conserved ...... ation of the v-Rel oncoprotein
@ast
The RxxRxRxxC motif conserved ...... ation of the v-Rel oncoprotein
@en
The RxxRxRxxC motif conserved ...... ation of the v-Rel oncoprotein
@nl
P2093
P2860
P356
P1476
The RxxRxRxxC motif conserved ...... ation of the v-Rel oncoprotein
@en
P2093
P2860
P304
P356
10.1128/MCB.12.7.3094
P407
P577
1992-07-01T00:00:00Z