The adenovirus E4 17-kilodalton protein complexes with the cellular transcription factor E2F, altering its DNA-binding properties and stimulating E1A-independent accumulation of E2 mRNA.
about
E1B 55-kilodalton-associated protein: a cellular protein with RNA-binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAsDP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 proteinAdenovirus type 5 early region 1B 55K oncoprotein-dependent degradation of cellular factor Daxx is required for efficient transformation of primary rodent cellsTip60 degradation by adenovirus relieves transcriptional repression of viral transcriptional activator EIA.SPOC1-mediated antiviral host cell response is antagonized early in human adenovirus type 5 infectionInduction of c-fos mRNA and AP-1 DNA-binding activity by cAMP in cooperation with either the adenovirus 243- or the adenovirus 289-amino acid E1A protein.Full genome sequence analysis of a novel adenovirus of rhesus macaque origin indicates a new simian adenovirus type and species.Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells.Adenovirus E4orf6 oncoprotein modulates the function of the p53-related protein, p73Analysis of synthesis, stability, phosphorylation, and interacting polypeptides of the 34-kilodalton product of open reading frame 6 of the early region 4 protein of human adenovirus type 5Transforming potential of the adenovirus type 5 E4orf3 protein.The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis.Induction of the cellular E2F-1 promoter by the adenovirus E4-6/7 protein.The E4-6/7 protein functionally compensates for the loss of E1A expression in adenovirus infectionAn arginine-faced amphipathic alpha helix is required for adenovirus type 5 e4orf6 protein functionInduction of transformation and p53-dependent apoptosis by adenovirus type 5 E4orf6/7 cDNA.E4orf6 variants with separate abilities to augment adenovirus replication and direct nuclear localization of the E1B 55-kilodalton protein.Recombinant adenoviral vectors can induce expression of p73 via the E4-orf6/7 proteinAn activity associated with human chromosome 21 permits nuclear colocalization of the adenovirus E1B-55K and E4orf6 proteins and promotes viral late gene expression.Adenovirus replaces mitotic checkpoint controls.The C-terminal 70 amino acids of the adenovirus E4-ORF6/7 protein are essential and sufficient for E2F complex formationAdenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosisAdenovirus early region 4 34-kilodalton protein directs the nuclear localization of the early region 1B 55-kilodalton protein in primate cells.Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy.A carboxy-terminal region required by the adenovirus type 9 E4 ORF1 oncoprotein for transformation mediates direct binding to cellular polypeptides.The adenovirus E4orf6 protein can promote E1A/E1B-induced focus formation by interfering with p53 tumor suppressor functionTranscription factor E2F binds DNA as a heterodimerKAP1 Is a Host Restriction Factor That Promotes Human Adenovirus E1B-55K SUMO ModificationControl of mRNA export by adenovirus E4orf6 and E1B55K proteins during productive infection requires E4orf6 ubiquitin ligase activityHeterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein.Adenovirus type 9 E4 open reading frame 1 encodes a transforming protein required for the production of mammary tumors in ratsMutually exclusive interaction of the adenovirus E4-6/7 protein and the retinoblastoma gene product with internal domains of E2F-1 and DP-1.The adenovirus E4-6/7 protein transactivates the E2 promoter by inducing dimerization of a heteromeric E2F complexAdenovirus E4-dependent activation of the early E2 promoter is insufficient to promote the early-to-late-phase transitionCell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F.NF-IL6, a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A.Defective synthesis of early region 4 mRNAs during abortive adenovirus infections in monkey cellsAdenovirus E4orf4 protein reduces phosphorylation of c-Fos and E1A proteins while simultaneously reducing the level of AP-1Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domainsRUNX1 permits E4orf6-directed nuclear localization of the adenovirus E1B-55K protein and associates with centers of viral DNA and RNA synthesis
P2860
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P2860
The adenovirus E4 17-kilodalton protein complexes with the cellular transcription factor E2F, altering its DNA-binding properties and stimulating E1A-independent accumulation of E2 mRNA.
description
1990 nî lūn-bûn
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1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
The adenovirus E4 17-kilodalto ...... ndent accumulation of E2 mRNA.
@ast
The adenovirus E4 17-kilodalto ...... ndent accumulation of E2 mRNA.
@en
type
label
The adenovirus E4 17-kilodalto ...... ndent accumulation of E2 mRNA.
@ast
The adenovirus E4 17-kilodalto ...... ndent accumulation of E2 mRNA.
@en
prefLabel
The adenovirus E4 17-kilodalto ...... ndent accumulation of E2 mRNA.
@ast
The adenovirus E4 17-kilodalto ...... ndent accumulation of E2 mRNA.
@en
P2093
P2860
P1433
P1476
The adenovirus E4 17-kilodalto ...... ndent accumulation of E2 mRNA.
@en
P2093
P2860
P304
P407
P577
1990-05-01T00:00:00Z