Novel strategies for inhibition of the p38 MAPK pathway.
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A distinct interaction mode revealed by the crystal structure of the kinase p38α with the MAPK binding domain of the phosphatase MKP5Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipidTherapeutic targets in the ASK1-dependent stress signaling pathwaysImpeding the interaction between Nur77 and p38 reduces LPS-induced inflammationp38 MAP kinases in the heartThe potential of p38 MAPK inhibitors to modulate periodontal infections.Selective unresponsiveness to the inhibition of p38 MAPK activation by cAMP helps L929 fibroblastoma cells escape TNF-alpha-induced cell death.Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse.New approaches to the design and discovery of therapies to prevent erectile dysfunction.Tandem mass spectrometry study of p38α kinase inhibitors and related substances.MAPKs represent novel therapeutic targets for gastrointestinal motility disorders.Innovations in studying in vivo cell behavior and pharmacology in complex tissues--microvascular endothelial cells in the spotlight.p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype.Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction.Inhibition of the protein kinase MK-2 protects podocytes from nephrotic syndrome-related injuryLack of the T cell-specific alternative p38 activation pathway reduces autoimmunity and inflammationIn vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.Activation of mitogen-activated protein kinases by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) plays an important role in macrophage stimulationNF-kappaB, but not p38 MAP kinase, is required for TNF-alpha-induced expression of cell adhesion molecules in endothelial cells.On-line electrochemistry-bioaffinity screening with parallel HR-LC-MS for the generation and characterization of modified p38α kinase inhibitors.A cell-based screening assay to identify pharmaceutical compounds that enhance the regenerative quality of corneal repair.Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infectionPhosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway.RACK1 antagonizes TNF-α-induced cell death by promoting p38 activation.NF-κB-dependent microRNA-125b up-regulation promotes cell survival by targeting p38α upon ultraviolet radiationUnique MAP Kinase binding sitesDifferential expression of p38 MAPK α, β, γ, δ isoforms in nucleus pulposus modulates macrophage polarization in intervertebral disc degeneration.Aspirin may promote mitochondrial biogenesis via the production of hydrogen peroxide and the induction of Sirtuin1/PGC-1α genes.Targeting systemic inflammation: novel therapies for the treatment of chronic obstructive pulmonary disease.The role of p38 in mitochondrial respiration in male and female miceSeeking approval: present and future therapies for pemphigus vulgarisDisruption of TAB1/p38α interaction using a cell-permeable peptide limits myocardial ischemia/reperfusion injury.Mitogen-activated protein kinases as therapeutic targets in osteoarthritis.Visceral pain triggered by traction on the ileocecal ligament with ileitis.A requirement of serotonergic p38α mitogen-activated protein kinase for peripheral immune system activation of CNS serotonin uptake and serotonin-linked behaviors.Characterization of a novel MK3 splice variant from murine ventricular myocardium.Developing small molecules to inhibit kinases unkind to the heart: p38 MAPK as a case in point.Emerging drugs for chronic obstructive pulmonary disease.Targeting kinases for the treatment of inflammatory diseases.p38 MAPK inhibitors: a patent review (2012 - 2013).
P2860
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P2860
Novel strategies for inhibition of the p38 MAPK pathway.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Novel strategies for inhibition of the p38 MAPK pathway.
@ast
Novel strategies for inhibition of the p38 MAPK pathway.
@en
type
label
Novel strategies for inhibition of the p38 MAPK pathway.
@ast
Novel strategies for inhibition of the p38 MAPK pathway.
@en
prefLabel
Novel strategies for inhibition of the p38 MAPK pathway.
@ast
Novel strategies for inhibition of the p38 MAPK pathway.
@en
P1476
Novel strategies for inhibition of the p38 MAPK pathway
@en
P2093
Anning Lin
Beifen Shen
P304
P356
10.1016/J.TIPS.2007.04.008
P50
P577
2007-05-07T00:00:00Z