Live and let die: in vivo selection of gene-modified hematopoietic stem cells via MGMT-mediated chemoprotection - Wikidata - awgldk - TriplyDB

Live and let die: in vivo selection of gene-modified hematopoietic stem cells via MGMT-mediated chemoprotection

Live and let die: in vivo selection of gene-modified hematopoietic stem cells via MGMT-mediated chemoprotection

http://www.wikidata.org/entity/Q36812597

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Efficient selection of genetically modified human T cells using methotrexate-resistant human dihydrofolate reductase.Genetic modification of mouse bone marrow by lentiviral vector-mediated delivery of hypoxanthine-Guanine phosphoribosyltransferase short hairpin RNA confers chemoprotection against 6-thioguanine cytotoxicity.Combined preconditioning and in vivo chemoselection with 6-thioguanine alone achieves highly efficient reconstitution of normal hematopoiesis with HPRT-deficient bone marrow Imaging stem cell-derived persistent foci after in vivo selection of lentiviral MGMT-P140K transduced murine bone marrow cells.Foamy viral vector integration sites in SCID-repopulating cells after MGMTP140K-mediated in vivo selection Efficiency and safety of O⁶-methylguanine DNA methyltransferase (MGMT(P140K))-mediated in vivo selection in a humanized mouse model Novel cell and gene therapies for HIV.Myeloprotection by cytidine deaminase gene transfer in antileukemic therapy.In vivo selection of hematopoietic stem cells transduced at a low multiplicity-of-infection with a foamy viral MGMT(P140K) vector.Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells.

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P2860

Live and let die: in vivo selection of gene-modified hematopoietic stem cells via MGMT-mediated chemoprotection

http://www.wikidata.org/entity/Q36812597

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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Live and let die: in vivo sele ...... MGMT-mediated chemoprotection

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Live and let die: in vivo sele ...... MGMT-mediated chemoprotection

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Live and let die: in vivo sele ...... MGMT-mediated chemoprotection

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Live and let die: in vivo sele ...... MGMT-mediated chemoprotection

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Live and let die: in vivo sele ...... MGMT-mediated chemoprotection

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J.DNAREP.2007.03.020

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Live and let die: in vivo sele ...... MGMT-mediated chemoprotection

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David A Williams

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Michael D Milsom

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P2860

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

Gene therapy: therapeutic gene causing lymphoma

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

O6-alkylguanine-DNA alkyltransferase inactivation in cancer chemotherapy.

Selection of drug-resistant transduced cells with cytosine nucleoside analogs using the human cytidine deaminase gene.

Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector.

Limited lentiviral transgene expression with increasing copy number in an MGMT selection model: lack of copy number selection by drug treatment.

A phase II trial of O6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma.

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1210-1221

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10.1016/J.DNAREP.2007.03.020

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