Random mutagenesis of Thermus aquaticus DNA polymerase I: concordance of immutable sites in vivo with the crystal structure
about
Modified Nucleoside Triphosphates for In-vitro Selection TechniquesReprogramming cells with synthetic proteinsDNA polymerase delta in DNA replication and genome maintenanceMolecular dynamics study of the opening mechanism for DNA polymerase IReplication through an abasic DNA lesion: structural basis for adenine selectivityAmino Acid Templating Mechanisms in Selection of Nucleotides Opposite Abasic Sites by a Family A DNA PolymeraseProtein tolerance to random amino acid changeMolecular breeding of polymerases for amplification of ancient DNACrystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation.Enzymatic properties of rat DNA polymerase beta mutants obtained by randomized mutagenesisDNA polymerase active site is highly mutable: evolutionary consequences.Assignment of functional amino acids around the active site of human DNA topoisomerase IIalpha.Distinct function of conserved amino acids in the fingers of Saccharomyces cerevisiae DNA polymerase alpha.The use of biosensor technology for the engineering of antibodies and enzymes.CyDNA: synthesis and replication of highly Cy-dye substituted DNA by an evolved polymerase.Evolutionary conservation of residues in vertebrate DNA polymerase N conferring low fidelity and bypass activityMutant Thermotoga neapolitana DNA polymerase I: altered catalytic properties for non-templated nucleotide addition and incorporation of correct nucleotides.Discovery of superior enzymes by directed molecular evolution.Directed evolution of polymerase function by compartmentalized self-replicationConserved overlapping gene arrangement, restricted expression, and biochemical activities of DNA polymerase ν (POLN).Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity.Prechemistry nucleotide selection checkpoints in the reaction pathway of DNA polymerase I and roles of glu710 and tyr766.Directed polymerase evolution.The Gly-952 residue of Saccharomyces cerevisiae DNA polymerase alpha is important in discriminating correct deoxyribonucleotides from incorrect ones.Arg660Ser mutation in Thermus aquaticus DNA polymerase I suppresses T-->C transitions: implication of wobble base pair formation at the nucleotide incorporation step.Insertion of the T3 DNA polymerase thioredoxin binding domain enhances the processivity and fidelity of Taq DNA polymerase.Evolving a polymerase for hydrophobic base analogues.Exploring the Chemistry of Genetic Information Storage and Propagation through Polymerase Engineering.Crystal structures of the Klenow fragment of Thermus aquaticus DNA polymerase I complexed with deoxyribonucleoside triphosphates.O-helix mutant T664P of Thermus aquaticus DNA polymerase I: altered catalytic properties for incorporation of incorrect nucleotides but not correct nucleotides.Substitution of ribonucleotides in the T7 RNA polymerase promoter element.Low fidelity mutants in the O-helix of Thermus aquaticus DNA polymerase I.
P2860
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P2860
Random mutagenesis of Thermus aquaticus DNA polymerase I: concordance of immutable sites in vivo with the crystal structure
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Random mutagenesis of Thermus ...... ivo with the crystal structure
@ast
Random mutagenesis of Thermus ...... ivo with the crystal structure
@en
type
label
Random mutagenesis of Thermus ...... ivo with the crystal structure
@ast
Random mutagenesis of Thermus ...... ivo with the crystal structure
@en
prefLabel
Random mutagenesis of Thermus ...... ivo with the crystal structure
@ast
Random mutagenesis of Thermus ...... ivo with the crystal structure
@en
P2093
P2860
P356
P1476
Random mutagenesis of Thermus ...... ivo with the crystal structure
@en
P2093
P2860
P304
P356
10.1073/PNAS.93.18.9670
P407
P577
1996-09-01T00:00:00Z