A role for the epithelial-cell-specific tyrosine kinase Sik during keratinocyte differentiation
about
Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding abilityRegulated association of protein kinase B/Akt with breast tumor kinaseSolution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domainProtein-tyrosine kinase 6 promotes peripheral adhesion complex formation and cell migration by phosphorylating p130 CRK-associated substrateProtein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factorBrk/Protein tyrosine kinase 6 phosphorylates p27KIP1, regulating the activity of cyclin D-cyclin-dependent kinase 4PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylationAltered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells'Srcasm: a novel Src activating and signaling moleculeProtein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestineDetection of Brk expression in non-small cell lung cancer: clinicopathological relevance.The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of β-cateninAn intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6.Interaction between Brk kinase and insulin receptor substrate-4.Brk/PTK6 signaling in normal and cancer cell models.Signal transduction pathways controlling the switch between keratinocyte growth and differentiation.Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRKMechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression.Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells.Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.Srcasm modulates EGF and Src-kinase signaling in keratinocytes.RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK.Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rakCytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cells.Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.Protein Tyrosine Kinase 6 Regulates UVB-Induced Signaling and Tumorigenesis in Mouse Skin.Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition.Protein tyrosine kinase 6 is associated with nasopharyngeal carcinoma poor prognosis and metastasis.Induction of protein tyrosine kinase 6 in mouse intestinal crypt epithelial cells promotes DNA damage-induced apoptosis.Protein tyrosine kinase 6 regulates mammary gland tumorigenesis in mouse models.Context-specific protein tyrosine kinase 6 (PTK6) signalling in prostate cancer.Role of breast tumour kinase in the in vitro differentiation of HaCaT cells.PTK6 activation at the membrane regulates epithelial-mesenchymal transition in prostate cancer.Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2.Breast tumor kinase (Brk/PTK6) plays a role in the differentiation of primary keratinocytes.Downregulated expression of PTK6 is correlated with poor survival in esophageal squamous cell carcinoma.Use of RNA interference to validate Brk as a novel therapeutic target in breast cancer: Brk promotes breast carcinoma cell proliferation.
P2860
Q22254678-60E4FAAD-ACD7-47DA-B9AE-691B0EDF0F29Q24314300-334F5118-15CD-4D3F-B350-5A5C41EBDC3CQ24322847-FD13B7CC-DC8C-49BC-8168-B9460749E124Q28115210-EAE049E1-867F-4F85-831A-27FEA1EC6CF0Q28115391-C681F5FE-5B75-42B6-AA00-8EBDF676BDCEQ28115769-1CE6FB7B-5DF1-44AE-8DAF-3B38F10BD775Q28116075-020EF793-1FD8-44C1-99F2-D93CD9675799Q28140199-9B7D34C3-E4FF-4F1E-BD8C-02107335E561Q28183216-7D529B3D-D73B-427E-B5B8-8C8E35E96104Q28505622-A0D52CCF-271B-4B9D-B9FC-3FF8A29385E6Q28509681-BF1A16EE-C0B6-4BE0-A06E-BC8D94FFA2FFQ30010489-D0966C98-1128-4255-B088-11F278F00DA7Q30155592-D680B08F-CF1C-468E-8A6B-C1B24739CC0FQ30160209-2105134C-35C1-4C27-B40F-A2E07D0D75FEQ30160247-A948396F-6C5E-4314-BB69-2D666C953CB8Q33690176-835C8E8E-52D8-429A-8BE7-4C58B35972B5Q33817051-EA5DF9ED-5DC3-4023-ABA5-02A8E2A991DAQ33912469-3C770AB9-6D84-4652-B0A4-2DD4E4C58ABDQ34085432-AD4FA993-AA37-472E-AA77-8A0682C90B0DQ34173535-15374F7B-5F12-40C6-B7F9-236C4022F1C3Q34195298-DB9C1F73-9C3B-4201-A3FF-4A02FA4A3027Q34227580-7FEBD550-2CCD-41B9-BEEB-5110B4273098Q34373519-3963346B-2A45-4214-B4B5-1A7BB4A8A0D3Q34420665-AB668516-CDC2-4660-97FA-7E2DC223E4B1Q34441584-074C52BA-DF90-4E4B-9B98-268ACA301D31Q34659926-D2964E5C-A4D0-4C26-8AE7-F7703650AE64Q35088231-8F0641BF-0D2D-4873-9938-5AF8DCE1B29CQ36054456-59B84056-AF2D-424A-931A-5B5989FB3605Q36677706-1C100E86-43A2-432F-96F7-EDA0CA9A70EEQ36940726-030BC0E9-EB76-4EA9-ACEC-4288803AE5D5Q37399415-8359C21F-619E-44B8-BBE7-FCFB6608D0ADQ37614521-850D49D1-8686-4D22-A735-9955DB6E770AQ38080556-BD676B34-AD93-44A9-82BA-C0AE26EC9E84Q38441536-3E320E44-530B-46DA-8ABF-0D085DD0F089Q39125642-6AB9098A-9E5C-4D0C-B942-75F132CAB4C7Q40369987-CBECD255-37FE-4B52-AB70-9E4CFC9C9F60Q40506613-A0488341-D960-45DF-BDDA-8D402147FBF7Q41910587-33AA4AB9-2329-4863-B991-28B7CA4A0D78Q44349158-29E202CF-5E54-4EB1-845C-94548A9E3B1DQ44539661-BD623F93-DE6B-4749-91F5-5E14A92F2A18
P2860
A role for the epithelial-cell-specific tyrosine kinase Sik during keratinocyte differentiation
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
A role for the epithelial-cell ...... g keratinocyte differentiation
@en
type
label
A role for the epithelial-cell ...... g keratinocyte differentiation
@en
prefLabel
A role for the epithelial-cell ...... g keratinocyte differentiation
@en
P2860
P356
P1476
A role for the epithelial-cell ...... g keratinocyte differentiation
@en
P2093
P2860
P304
14477-14482
P356
10.1073/PNAS.94.26.14477
P407
P50
P577
1997-12-01T00:00:00Z