Regulated association of protein kinase B/Akt with breast tumor kinase - Wikidata - awgldk - TriplyDB

Regulated association of protein kinase B/Akt with breast tumor kinase

Regulated association of protein kinase B/Akt with breast tumor kinase

http://www.wikidata.org/entity/Q24314300

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In situ quantification of HER2-protein tyrosine kinase 6 (PTK6) protein-protein complexes in paraffin sections from breast cancer tissues Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1 Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine TNFα/IFNγ Mediated Intestinal Epithelial Barrier Dysfunction Is Attenuated by MicroRNA-93 Downregulation of PTK6 in Mouse Colonic Epithelial Cells Low expression of PTK6/Brk predicts poor prognosis in patients with laryngeal squamous cell carcinoma.The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of β-catenin An intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6.Interaction between Brk kinase and insulin receptor substrate-4.Physiological regulation of Akt activity and stability.Brk/PTK6 signaling in normal and cancer cell models.Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRK Mechanisms of HGF/Met signaling to Brk and Sam68 in breast cancer progression.Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells.RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK.Cytoplasmic retention of protein tyrosine kinase 6 promotes growth of prostate tumor cells.New targeted therapies for breast cancer: A focus on tumor microenvironmental signals and chemoresistant breast cancers Expression and oncogenic role of Brk (PTK6/Sik) protein tyrosine kinase in lymphocytes.BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration.PTK6 promotes cancer migration and invasion in pancreatic cancer cells dependent on ERK signaling.Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR PTK (protein tyrosine kinase)-6 and HER2 and 4, but not HER1 and 3 predict long-term survival in breast carcinomas.Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition.Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients.Brk protects breast cancer cells from autophagic cell death induced by loss of anchorage.Induction of protein tyrosine kinase 6 in mouse intestinal crypt epithelial cells promotes DNA damage-induced apoptosis.The marine-derived pachycladin diterpenoids as novel inhibitors of wild-type and mutant EGFR.Additive impact of HER2-/PTK6-RNAi on interactions with HER3 or IGF-1R leads to reduced breast cancer progression in vivo.Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells.Impact of protein tyrosine kinase 6 (PTK6) on human epidermal growth factor receptor (HER) signalling in breast cancer.The essential role of the death domain kinase receptor-interacting protein in insulin growth factor-I-induced c-Jun N-terminal kinase activation.Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression.Breast tumor kinase (Brk/PTK6) plays a role in the differentiation of primary keratinocytes.Downregulated expression of PTK6 is correlated with poor survival in esophageal squamous cell carcinoma.Signaling by PTK6 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 PTK6 phosphorylates AKT1 Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.

P2860

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P2860

Regulated association of protein kinase B/Akt with breast tumor kinase

http://www.wikidata.org/entity/Q24314300

description

2005 nî lūn-bûn

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2005 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2005 թվականի հունվարին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Regulated association of protein kinase B/Akt with breast tumor kinase

@ast

Regulated association of protein kinase B/Akt with breast tumor kinase

@en

Regulated association of protein kinase B/Akt with breast tumor kinase

@en-gb

Regulated association of protein kinase B/Akt with breast tumor kinase

@nl

type

label

Regulated association of protein kinase B/Akt with breast tumor kinase

@ast

Regulated association of protein kinase B/Akt with breast tumor kinase

@en

Regulated association of protein kinase B/Akt with breast tumor kinase

@en-gb

Regulated association of protein kinase B/Akt with breast tumor kinase

@nl

prefLabel

Regulated association of protein kinase B/Akt with breast tumor kinase

@ast

Regulated association of protein kinase B/Akt with breast tumor kinase

@en

Regulated association of protein kinase B/Akt with breast tumor kinase

@en-gb

Regulated association of protein kinase B/Akt with breast tumor kinase

@nl

P1433

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P1476

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P2093

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P3181

P356

P1433

Journal of Biological Chemistry

P1476

Regulated association of protein kinase B/Akt with breast tumor kinase

@en

P2093

Abby Olsen

http://www.w3.org/2001/XMLSchema#string

Carol A Lange

http://www.w3.org/2001/XMLSchema#string

Daniel Fitzsimmons

http://www.w3.org/2001/XMLSchema#string

Emily J Faivre

http://www.w3.org/2001/XMLSchema#string

Julie Hanson Ostrander

http://www.w3.org/2001/XMLSchema#string

Ping Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability

Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition

TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain

Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK.

A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK

Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation

Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells

Role of the Brk SH3 domain in substrate recognition

Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases

P304

1982-91

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

2057039

http://www.w3.org/2001/XMLSchema#string

P356

10.1074/JBC.M412038200

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P407

P433

3

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P478

280

http://www.w3.org/2001/XMLSchema#string

P577

2005-01-21T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

15539407

http://www.w3.org/2001/XMLSchema#string

P921

negative regulation of protein tyrosine kinase activity

Protein tyrosine kinase 6