Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21(Cip1).
about
An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stressDNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B.Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development.Ku70 Serine 155 mediates Aurora B inhibition and activation of the DNA damage response.Aurora B: hooking up with cyclin-dependent kinases.Less understood issues: p21(Cip1) in mitosis and its therapeutic potential.Effect of reversine on cell cycle, apoptosis, and activation of hepatic stellate cells.Induction of p21CIP1 protein and cell cycle arrest after inhibition of Aurora B kinase is attributed to aneuploidy and reactive oxygen species.p21Waf1/Cip1 deficiency causes multiple mitotic defects in tumor cells.Clinical Development of Anti-mitotic Drugs in Cancer.A role for p38 in transcriptional elongation of p21 (CIP1) in response to Aurora B inhibitionVRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis.
P2860
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P2860
Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21(Cip1).
description
2013 nî lūn-bûn
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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2013年论文
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2013年论文
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name
Aurora B prevents delayed DNA ...... exit by repressing p21(Cip1).
@en
type
label
Aurora B prevents delayed DNA ...... exit by repressing p21(Cip1).
@en
prefLabel
Aurora B prevents delayed DNA ...... exit by repressing p21(Cip1).
@en
P2860
P50
P356
P1433
P1476
Aurora B prevents delayed DNA ...... exit by repressing p21(Cip1).
@en
P2093
Christopher Heeschen
Gonzalo Fernández-Miranda
P2860
P304
P356
10.4161/CC.24004
P577
2013-02-21T00:00:00Z