Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice
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Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activationDifferential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosisModeling the study of DNA damage responses in miceExamination of the expanding pathways for the regulation of p21 expression and activity.The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with AtmMutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombinationp21 in cancer: intricate networks and multiple activitiesAtm deletion with dual recombinase technology preferentially radiosensitizes tumor endotheliumLimited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.Ataxia-telangiectasia, cancer and the pathobiology of the ATM gene.Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice.Expression of p21 protein predicts clinical outcome in DLBCL patients older than 60 years treated with R-CHOP but not CHOP: a prospective ECOG and Southwest Oncology Group correlative study on E4494.Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypesHuman bone marrow stromal cells display variable anatomic site-dependent response and recovery from irradiationGenetic analysis of mammalian cyclin-dependent kinases and their inhibitors.TSPYL2 is important for G1 checkpoint maintenance upon DNA damage.Atm is dispensable for p53 apoptosis and tumor suppression triggered by cell cycle dysfunction.Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.Strategies for manipulating the p53 pathway in the treatment of human cancer.PRAP1 is a novel executor of p53-dependent mechanisms in cell survival after DNA damage.ATM signalling and cancer."Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normallyActivation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasisMutation of NIMA-related kinase 1 (NEK1) leads to chromosome instabilityEpimorphic regeneration in mice is p53-independentp16(INK4A) positively regulates p21(WAF1) expression by suppressing AUF1-dependent mRNA decay.Cellular senescence and organismal ageing in the absence of p21(CIP1/WAF1) in ku80(-/-) mice.Uncoupling p53 functions in radiation-induced intestinal damage via PUMA and p21.Armoring CRAds with p21/Waf-1 shRNAs: the next generation of oncolytic adenoviruses.P21Waf1 control of epithelial cell cycle and cell fate.Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivityDifferential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletionInactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stressThe role of the ubiquitin/proteasome system in cellular responses to radiation.CDKN1A and FANCD2 are potential oncotargets in Burkitt lymphoma and multiple myelomaDifferent responses of epidermal and hair follicular cells to radiation correlate with distinct patterns of p53 and p21 induction.CLCA2 as a p53-inducible senescence mediator.Visualizing the dynamics of p21(Waf1/Cip1) cyclin-dependent kinase inhibitor expression in living animals.Cervical Cancer Genetic Susceptibility: A Systematic Review and Meta-Analyses of Recent EvidenceOncogenic role of p21 in hepatocarcinogenesis suggests a new treatment strategy.
P2860
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P2860
Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Loss of p21 increases sensitiv ...... lymphoma in atm-deficient mice
@en
type
label
Loss of p21 increases sensitiv ...... lymphoma in atm-deficient mice
@en
prefLabel
Loss of p21 increases sensitiv ...... lymphoma in atm-deficient mice
@en
P2093
P2860
P356
P1476
Loss of p21 increases sensitiv ...... lymphoma in atm-deficient mice
@en
P2093
P2860
P304
14590-14595
P356
10.1073/PNAS.94.26.14590
P407
P577
1997-12-01T00:00:00Z