Leukemogenic membrane glycoprotein encoded by Friend spleen focus-forming virus: transport to cell surfaces and shedding are controlled by disulfide-bonded dimerization and by cleavage of a hydrophobic membrane anchor.
about
The envelope glycoprotein of an amphotropic murine retrovirus binds specifically to the cellular receptor/phosphate transporter of susceptible speciesActivation of the N-terminally truncated form of the Stk receptor tyrosine kinase Sf-Stk by Friend virus-encoded gp55 is mediated by cysteine residues in the ecotropic domain of gp55 and the extracellular domain of Sf-Stk.Sequence flexibility in the polytropic env gp70-derived region of the membrane glycoprotein (gp55) of Friend spleen focus-forming virus affects its biological activity.Origin and rapid evolution of a novel murine erythroleukemia virus of the spleen focus-forming virus family.An array of novel murine spleen focus-forming viruses that activate the erythropoietin receptor.Activation of erythropoietin receptors by Friend viral gp55 and by erythropoietin and down-modulation by the murine Fv-2r resistance gene.Friend Spleen Focus-Forming Virus Activates the Tyrosine Kinase sf-Stk and the Transcription Factor PU.1 to Cause a Multi-Stage Erythroleukemia in Mice.Deletions in one domain of the Friend virus-encoded membrane glycoprotein overcome host range restrictions for erythroleukemia.Cell surface activation of the erythropoietin receptor by Friend spleen focus-forming virus gp55.A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia.A Friend virus mutant that overcomes Fv-2rr host resistance encodes a small glycoprotein that dimerizes, is processed to cell surfaces, and specifically activates erythropoietin receptors.Analysis of the functional and host range-determining regions of the murine ectropic and amphotropic retrovirus envelope proteinsThe Ets-related transcription factor PU.1 immortalizes erythroblastsThe hydrophobic membrane-spanning sequences of the gp52 glycoprotein are required for the pathogenicity of Friend spleen focus-forming virus.A deletion in the Friend spleen focus-forming virus env gene is necessary for its product (gp55) to be leukemogenic.Role of the PU.1 transcription factor in controlling differentiation of Friend erythroleukemia cells.Spontaneous solubilization of membrane-bound human testis angiotensin-converting enzyme expressed in Chinese hamster ovary cells.Both the changes of six amino acids and the C-terminal truncation caused by a one-base insertion in the defective env gene of Friend spleen focus-forming virus significantly affect the pathogenic activity of the encoded leukemogenic membrane glycoprErythropoietin receptor (EpoR)-dependent mitogenicity of spleen focus-forming virus correlates with viral pathogenicity and processing of env protein but not with formation of gp52-EpoR complexes in the endoplasmic reticulum.Membrane protein secretasesFusion of the erythropoietin receptor and the Friend spleen focus-forming virus gp55 glycoprotein transforms a factor-dependent hematopoietic cell line.
P2860
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P2860
Leukemogenic membrane glycoprotein encoded by Friend spleen focus-forming virus: transport to cell surfaces and shedding are controlled by disulfide-bonded dimerization and by cleavage of a hydrophobic membrane anchor.
description
1989 nî lūn-bûn
@nan
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
1989年论文
@zh
1989年论文
@zh-cn
name
Leukemogenic membrane glycopro ...... a hydrophobic membrane anchor.
@en
type
label
Leukemogenic membrane glycopro ...... a hydrophobic membrane anchor.
@en
prefLabel
Leukemogenic membrane glycopro ...... a hydrophobic membrane anchor.
@en
P2860
P1433
P1476
Leukemogenic membrane glycopro ...... a hydrophobic membrane anchor.
@en
P2093
P2860
P304
P407
P577
1989-09-01T00:00:00Z