Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation - Wikidata - awgldk - TriplyDB

Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation

Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation

http://www.wikidata.org/entity/Q36832181

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Learning about the Importance of Mutation Prevention from Curable Cancers and Benign Tumors The other side of the coin: the tumor-suppressive aspect of oncogenes and the oncogenic aspect of tumor-suppressive genes, such as those along the CCND-CDK4/6-RB axis Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.Iscador Qu inhibits doxorubicin-induced senescence of MCF7 cells Senescence gives insights into the morphogenetic evolution of anamniotes.Cellular senescence and protein degradation: breaking down cancer The MAPK pathway across different malignancies: a new perspective.Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression TSH signaling overcomes B-RafV600E-induced senescence in papillary thyroid carcinogenesis through regulation of DUSP6.Active ERK2 is sufficient to mediate growth arrest and differentiation signaling ACE-inhibition increases podocyte number in experimental glomerular disease independent of proliferation.Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-C.Let-7a regulates mammosphere formation capacity through Ras/NF-κB and Ras/MAPK/ERK pathway in breast cancer stem cells Two hydrophobic residues can determine the specificity of mitogen-activated protein kinase docking interactions.NKG2D ligands mediate immunosurveillance of senescent cells.From Ancient Pathways to Aging Cells-Connecting Metabolism and Cellular Senescence.TMEFF2 modulates the AKT and ERK signaling pathways IL-6-STAT3 signaling and premature senescence.S6K in geroconversion.MEK1 is required for the development of NRAS-driven leukemia.Cellular senescence and its effector programs.Physiological and pathological consequences of cellular senescence.Hutchinson-Gilford progeria syndrome as a model for vascular aging.Angiotensin II type 2 receptor-interacting protein 3a inhibits ovarian carcinoma metastasis via the extracellular HMGA2-mediated ERK/EMT pathway.Bis(acetylacetonato)-oxidovanadium(IV) and sodium metavanadate inhibit cell proliferation via ROS-induced sustained MAPK/ERK activation but with elevated AKT activity in human pancreatic cancer AsPC-1 cells.Context-specific flow through the MEK/ERK module produces cell- and ligand-specific patterns of ERK single and double phosphorylation.Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation.Mechanisms of oncogene-induced genomic instability.MEK drives cyclin D1 hyperelevation during geroconversion BAALC potentiates oncogenic ERK pathway through interactions with MEKK1 and KLF4.Raf kinase inhibitor protein regulates oxygen-glucose deprivation-induced PC12 cells apoptosis through the NF-κB and ERK pathways.Expression, prognosis and functional role of Thsd7a in esophageal squamous cell carcinoma of Kazakh patients, Xinjiang.Targeted protein degradation as a tumor suppressor.Epidermal growth factor receptor (EGFR)-MAPK-nuclear factor(NF)-κB-IL8: A possible mechanism of particulate matter(PM) 2.5-induced lung toxicity.Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence.Clinical Implications of NRAS Overexpression in Resectable Pancreatic Adenocarcinoma Patients.A Braf kinase-inactive mutant induces lung adenocarcinoma.Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway.Raf Kinase Inhibitor Protein Attenuates Ischemic-Induced Microglia Cell Apoptosis and Activation Through NF-κB Pathway.Short hairpin RNA-mediated gene silencing of ADAM17 inhibits the growth of breast cancer MCF‑7 cells in vitro and in vivo and its mechanism of action.

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Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation

http://www.wikidata.org/entity/Q36832181

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2013 nî lūn-bûn

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2013年の論文

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Tumor suppressor activity of t ...... selective protein degradation

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Tumor suppressor activity of t ...... selective protein degradation

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Fred Saad

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Frédéric Lessard

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Gerardo Ferbeyre

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Marc K Saba-El-Leil

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Marie-France Gaumont-Leclerc

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Olga Moiseeva

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Sebastian Igelmann

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Sylvain Meloche

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Véronique Bourdeau

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P2860

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis

CSIG inhibits PTEN translation in replicative senescence

Autophagy mediates the mitotic senescence transition

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

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10.1101/GAD.203984.112

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8

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27

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Anne-Marie Mes-Masson

Valérie Forest

Xavier Deschênes-Simard

Frédérick A Mallette

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2013-04-18T00:00:00Z

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236228429

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23599344

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3650227

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