A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. - Wikidata - awgldk - TriplyDB

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.

http://www.wikidata.org/entity/Q36835151

about

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2 Emerging role of sphingosine-1-phosphate signaling in head and neck squamous cell carcinoma The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined The emerging role of FTY720 (Fingolimod) in cancer treatment Characterization of isoenzyme-selective inhibitors of human sphingosine kinases Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent FTY720 induces apoptosis of M2 subtype acute myeloid leukemia cells by targeting sphingolipid metabolism and increasing endogenous ceramide levels The emergence of acid ceramidase as a therapeutic target for acute myeloid leukemia.Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking.Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia.The apoptotic mechanism of action of the sphingosine kinase 1 selective inhibitor SKI-178 in human acute myeloid leukemia cell lines.Structure-activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: discovery of SphK1- and SphK2-selective inhibitors.Drugging sphingosine kinases.Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate.Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors.Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate.Sphingosine 1-phosphate chemical biology Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells.Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors Sphingosine kinase activity is not required for tumor cell viability The Concise Guide to PHARMACOLOGY 2013/14: enzymes.Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets.Twofer anti-vascular therapy targeting sphingosine-1-phosphate for breast cancer.CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1 Re-configuration of sphingolipid metabolism by oncogenic transformation.Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget.Sphingosine kinase 1 in cancer.Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression S1P metabolism in cancer and other pathological conditions.Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription.Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.Single-cell sphingosine kinase activity measurements in primary leukemia Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond.Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching.Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics.The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells Sphingosine-1-phosphate and immune regulation: trafficking and beyond Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration Sphingosine kinase 1 serves as a pro-viral factor by regulating viral RNA synthesis and nuclear export of viral ribonucleoprotein complex upon influenza virus infection.

P2860

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P2860

A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.

http://www.wikidata.org/entity/Q36835151

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

A selective sphingosine kinase ...... tic targets in human leukemia.

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type

label

A selective sphingosine kinase ...... tic targets in human leukemia.

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A selective sphingosine kinase ...... tic targets in human leukemia.

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A selective sphingosine kinase ...... utic targets in human leukemia

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Barbara S Paugh

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Dmitri Kapitonov

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Jeffrey K Adams

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Jorge A Almenara

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Robert E Zipkin

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Sheldon Milstien

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Steven Grant

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Steven W Paugh

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Tomasz Kordula

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P2860

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling

Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling

Role of ABCC1 in export of sphingosine-1-phosphate from mast cells

Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases

Molecular cloning and functional characterization of murine sphingosine kinase

Sphingosine-1-phosphate: an enigmatic signalling lipid

Discovery and evaluation of inhibitors of human sphingosine kinase.

The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2.

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1382-1391

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scholarly article

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4

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112

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Mohamed Rahmani

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2008-05-29T00:00:00Z

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5338758

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18511810

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