Different functional domains of the adenovirus E1A gene are involved in regulation of host cell cycle products.
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In vivo structure of two divergent promoters at the human PCNA locus. Synthesis of antisense RNA and S phase-dependent binding of E2F complexes in intron 1A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasisp300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigenRole of adenovirus E1B proteins in transformation: altered organization of intermediate filaments in transformed cells that express the 19-kilodalton protein.Induction of AP-1 DNA-binding activity and c-fos mRNA by the adenovirus 243R E1A protein and cyclic AMP requires domains necessary for transformation.E1A promotes association between p300 and pRB in multimeric complexes required for normal biological activityInduction of c-fos mRNA and AP-1 DNA-binding activity by cAMP in cooperation with either the adenovirus 243- or the adenovirus 289-amino acid E1A protein.Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis.Expression of the pRb-binding regions of E1A enables efficient transformation of primary epithelial cells by v-src.The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis.Induction of transformation and p53-dependent apoptosis by adenovirus type 5 E4orf6/7 cDNA.Differential splicing yields novel adenovirus 5 E1A mRNAs that encode 30 kd and 35 kd proteins.Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein.Regulation of the human proliferating cell nuclear antigen promoter by the adenovirus E1A-associated protein p107Transcription factors RFX1/EF-C and ATF-1 associate with the adenovirus E1A-responsive element of the human proliferating cell nuclear antigen promoter.Repression of c-Myc and inhibition of G1 exit in cells conditionally overexpressing p300 that is not dependent on its histone acetyltransferase activityFunctions of the two adenovirus early E1A proteins and their conserved domains in cell cycle alteration, actin reorganization, and gene activation in rat cells.Adenovirus type 5 exerts genome-wide control over cellular programs governing proliferation, quiescence, and survival.Induction of susceptibility to tumor necrosis factor by E1A is dependent on binding to either p300 or p105-Rb and induction of DNA synthesisAccumulation of p53 induced by the adenovirus E1A protein requires regions involved in the stimulation of DNA synthesis.Upstream sequences of rice proliferating cell nuclear antigen (PCNA) gene mediate expression of PCNA-GUS chimeric gene in meristems of transgenic tobacco plants.Transcriptional coactivator cAMP response element binding protein mediates induction of the human proliferating cell nuclear antigen promoter by the adenovirus E1A oncoprotein.Np95 is regulated by E1A during mitotic reactivation of terminally differentiated cells and is essential for S phase entryConstructing chimeric type 12/type 5 adenovirus E1A genes and using them to identify an oncogenic determinant of adenovirus type 12.Functional importance of complex formation between the retinoblastoma tumor suppressor family and adenovirus E1A proteins as determined by mutational analysis of E1A conserved region 2Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growthThe adenovirus E1A 12S product displays functional redundancy in activating the human proliferating cell nuclear antigen promoterModulation of transcriptional activation of the proliferating cell nuclear antigen promoter by the adenovirus E1A 243-residue oncoprotein depends on proximal activatorsInduction of the cell cycle in baby rat kidney cells by adenovirus type 5 E1A in the absence of E1B and a possible influence of p53.The E1A products of oncogenic adenovirus serotype 12 include amino-terminally modified forms able to bind the retinoblastoma protein but not p300A complex promoter element mediates transactivation of the human proliferating cell nuclear antigen promoter by the 243-residue adenovirus E1A oncoproteinThe amino-terminal portion of CD1 of the adenovirus E1A proteins is required to induce susceptibility to tumor necrosis factor cytolysis in adenovirus-infected mouse cellsSimian virus 40 large-T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene productsAdenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins.E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteinsPromoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domainsImportance of introns in the growth regulation of mRNA levels of the proliferating cell nuclear antigen gene.E1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products.Analysis with specific polyclonal antiserum indicates that the E1A-associated 300-kDa product is a stable nuclear phosphoprotein that undergoes cell cycle phase-specific modification.A novel protein factor is required for use of distal alternative 5' splice sites in vitro.
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Different functional domains of the adenovirus E1A gene are involved in regulation of host cell cycle products.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
1987年论文
@zh
1987年论文
@zh-cn
name
Different functional domains o ...... n of host cell cycle products.
@en
type
label
Different functional domains o ...... n of host cell cycle products.
@en
prefLabel
Different functional domains o ...... n of host cell cycle products.
@en
P2093
P2860
P356
P1476
Different functional domains o ...... n of host cell cycle products.
@en
P2093
P2860
P304
P356
10.1128/MCB.7.2.821
P407
P577
1987-02-01T00:00:00Z