Expression of early adenovirus genes requires a viral encoded acidic polypeptide
about
Analysis of adenovirus transforming proteins from early regions 1A and 1B with antisera to inducible fusion antigens produced in Escherichia coli.The 289-amino acid E1A protein of adenovirus binds zinc in a region that is important for trans-activation.Phosphorylation-dependent activation of the adenovirus-inducible E2F transcription factor in a cell-free system.Differential splicing yields novel adenovirus 5 E1A mRNAs that encode 30 kd and 35 kd proteins.The release of growth arrest by microinjection of adenovirus E1A DNA.Adenovirus E1A protein activation of an integrated viral geneDissection of overlapping functions within the adenovirus type 5 E1A gene.Elimination of mRNA splicing by a point mutation outside the conserved GU at 5' splice sites.The E4 transcriptional unit of Ad2: far upstream sequences are required for its transactivation by E1A.Mutations in the E1a gene of adenovirus type 5 alter the tumorigenic properties of transformed cloned rat embryo fibroblast cells.Adenovirus type 12 early region 1A proteins repress class I HLA expression in transformed human cells.Adenovirus type 5 exerts genome-wide control over cellular programs governing proliferation, quiescence, and survival.Phosphorylation within the transactivation domain of adenovirus E1A protein by mitogen-activated protein kinase regulates expression of early region 4Readthrough activation of early adenovirus E1b gene transcription.Adenovirus early region 1A protein activates transcription of a nonviral gene introduced into mammalian cells by infection or transfection.Identification and mapping of polypeptides encoded by the P3HR-1 strain of Epstein-Barr virus.Individual products of the adenovirus 12S and 13S EIa mRNAs stimulate viral EIIa and EIII expression at the transcriptional levelThe adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2.Promoter-specific trans-activation by the adenovirus E1A12S product involves separate E1A domainstrans-dominant mutants of E1A provide genetic evidence that the zinc finger of the trans-activating domain binds a transcription factorFusion of adenovirus E1A to the glucocorticoid receptor by high-resolution deletion cloning creates a hormonally inducible viral transactivatorAdenovirus early region 4 is essential for normal stability of late nuclear RNAsDifferential requirement for adenovirus type 12 E1A gene products in oncogenic transformation.Characterization of a potent varicella-zoster virus-encoded trans-repressorcis-dominant defect in activation of adenovirus type 5 E1b early RNA synthesis.The efficiency of adenovirus transformation of rodent cells is inversely related to the rate of viral E1A gene expression.Two regions of the adenovirus early region 1A proteins are required for transformation.Limited temperature-sensitive transactivation by mutant adenovirus type 2 E1a proteins.The cellular transcription factor E2f requires viral E1A and E4 gene products for increased DNA-binding activity and functions to stimulate adenovirus E2A gene expressionAnalysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism.Different functional domains of the adenovirus E1A gene are involved in regulation of host cell cycle products.An adenovirus type 5 E1A protein with a single amino acid substitution blocks wild-type E1A transactivationThe amino-terminal region of the adenovirus serotype 5 E1a protein performs two separate functions when expressed in primary baby rat kidney cells.Adenovirus 5 early region 1A host range mutants hr3, hr4, and hr5 contain point mutations which generate single amino acid substitutions.Individual adenovirus type 5 early region 1A gene products elicit distinct alterations of cellular morphology and gene expression.Lytic and transforming functions of individual products of the adenovirus E1A gene.Adenoviral early region 4 is required for efficient viral DNA replication and for late gene expressionPosttranslational modification at the N terminus of the human adenovirus type 12 E1A 235R tumor antigen.Use of recombinant retroviruses to study the regulation of integrated adenovirus early promotersPartition of E1A proteins between soluble and structural fractions of adenovirus-infected and -transformed cells
P2860
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P2860
Expression of early adenovirus genes requires a viral encoded acidic polypeptide
description
1981 nî lūn-bûn
@nan
1981 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1981 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1981年の論文
@ja
1981年論文
@yue
1981年論文
@zh-hant
1981年論文
@zh-hk
1981年論文
@zh-mo
1981年論文
@zh-tw
1981年论文
@wuu
name
Expression of early adenovirus genes requires a viral encoded acidic polypeptide
@ast
Expression of early adenovirus genes requires a viral encoded acidic polypeptide
@en
Expression of early adenovirus genes requires a viral encoded acidic polypeptide
@nl
type
label
Expression of early adenovirus genes requires a viral encoded acidic polypeptide
@ast
Expression of early adenovirus genes requires a viral encoded acidic polypeptide
@en
Expression of early adenovirus genes requires a viral encoded acidic polypeptide
@nl
prefLabel
Expression of early adenovirus genes requires a viral encoded acidic polypeptide
@ast
Expression of early adenovirus genes requires a viral encoded acidic polypeptide
@en
Expression of early adenovirus genes requires a viral encoded acidic polypeptide
@nl
P2093
P2860
P356
P1476
Expression of early adenovirus genes requires a viral encoded acidic polypeptide
@en
P2093
B E Roberts
R P Ricciardi
P2860
P304
P356
10.1073/PNAS.78.10.6121
P407
P577
1981-10-01T00:00:00Z