TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia
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JAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indicationsThe Emerging Role of miRNAs in HTLV-1 Infection and ATLL PathogenesisNovel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive reviewThe role of aberrant proteolysis in lymphomagenesisVitamin D in hematological disorders and malignancies.Use of RNAi screens to uncover resistance mechanisms in cancer cells and identify synthetic lethal interactions.DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cellsNuclear lipid microdomain as resting place of dexamethasone to impair cell proliferation.Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemiaEmerging therapeutic paradigms to target the dysregulated Janus kinase/signal transducer and activator of transcription pathway in hematological malignanciesEfficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia.Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approachSTAT1: A Novel Target of miR-150 and miR-223 Is Involved in the Proliferation of HTLV-I-Transformed and ATL Cells.RBP2 Promotes Adult Acute Lymphoblastic Leukemia by Upregulating BCL2.Oncogenic role of miR-155 in anaplastic large cell lymphoma lacking the t(2;5) translocation.In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activityStructural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemiaIntracellular Signaling Pathways Involved in Childhood Acute Lymphoblastic Leukemia; Molecular TargetsThe TCA cycle transferase DLST is important for MYC-mediated leukemogenesis.Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia.Selective JAK inhibitors.Anti-leukaemic activity of the TYK2 selective inhibitor NDI-031301 in T-cell acute lymphoblastic leukaemia.Development of Selective Covalent Janus Kinase 3 Inhibitors.Clinical genomic profiling identifies TYK2 mutation and overexpression in patients with neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors.Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma.SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells.The genetics and molecular biology of T-ALL.Germline activating TYK2 mutations in pediatric patients with two primary acute lymphoblastic leukemia occurrences.Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK-STAT pathway in Sézary syndromeRNAi Screening of Leukemia Cells Using ElectroporationConditional ablation of TYK2 in immunity to viral infection and tumor surveillance.Genomic complexity and dynamics of clonal evolution in childhood acute myeloid leukemia studied with whole-exome sequencing.Structural modeling of JAK1 mutations in T-cell acute lymphoblastic leukemia reveals a second contact site between pseudokinase and kinase domains.Peptidomimetic blockade of MYB in acute myeloid leukemia.Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation.Role of Non Receptor Tyrosine Kinases in Hematological Malignances and its Targeting by Natural Products.RNAi Screening with Self-Delivering, Synthetic siRNAs for Identification of Genes That Regulate Primary Human T Cell Migration.Compound heterozygous TYK2 mutations underlie primary immunodeficiency with T-cell lymphopenia.Targeted therapies for T-cell acute lymphoblastic leukaemia (T-ALL): what makes T-ALL TYK?
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P2860
TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia
@en
type
label
TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia
@en
prefLabel
TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia
@en
P2093
P2860
P50
P1433
P1476
TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia
@en
P2093
A Thomas Look
Andrew P Weng
Catriona H M Jamieson
Donna S Neuberg
Jason Glover
Jessica Tatarek
Louis M Staudt
Maria Kleppe
Michelle A Kelliher
P2860
P304
P356
10.1158/2159-8290.CD-12-0504
P50
P577
2013-03-07T00:00:00Z