about
The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanismRoles of prohibitin in growth control and tumor suppression in human cancersIn vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.p38α MAPK and Type I Inhibitors: Binding Site Analysis and Use of Target Ensembles in Virtual Screening.A Comprehensive Structural Overview of p38α MAPK in Complex with Type I Inhibitors.The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen-Activated Protein Kinase Inhibitors.A computational workflow for the design of irreversible inhibitors of protein kinases.Activity prediction and structural insights of extracellular signal-regulated kinase 2 inhibitors with molecular dynamics simulations.A Comprehensive Structural Overview of p38α Mitogen-Activated Protein Kinase in Complex with ATP-Site and Non-ATP-Site Binders.Frontiers in Medicinal Chemistry 2009--a summary of the meeting at Heidelberg University.Role of Molecular Interactions and Protein Rearrangement in the Dissociation Kinetics of p38α MAP Kinase Type-I/II/III Inhibitors.Assessing protein kinase selectivity with molecular dynamics and mm-pbsa binding free energy calculations.
P2860
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P2860
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Are MAP kinases drug targets? Yes, but difficult ones.
@en
type
label
Are MAP kinases drug targets? Yes, but difficult ones.
@en
prefLabel
Are MAP kinases drug targets? Yes, but difficult ones.
@en
P2860
P356
P1433
P1476
Are MAP kinases drug targets? Yes, but difficult ones.
@en
P2093
Simona Margutti
Stefan A Laufer
P2860
P304
P356
10.1002/CMDC.200600271
P577
2007-08-01T00:00:00Z