Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
about
A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathwayNSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathwayHuman JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factorScaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathwayDirect activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 (MEKK) derivativep110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytesA novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3Regulation of 5'-AMP-activated protein kinase activity by the noncatalytic beta and gamma subunitsCharacterization of the structure and function of a new mitogen-activated protein kinase (p38beta)Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuliMolecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brainCloning and characterization of a human STE20-like protein kinase with unusual cofactor requirementsActivation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinaseCharacterization of the structure and function of a novel MAP kinase kinase (MKK6)Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKAIndependent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liverMolecular and cellular targetsMitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinaseHuman OGA binds substrates in a conserved peptide recognition grooveA 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptorsTNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase relatedMediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substratesThe proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathwayAkt (protein kinase B) negatively regulates SEK1 by means of protein phosphorylationInduction of apoptosis by protein inhibitor of activated Stat1 through c-Jun NH2-terminal kinase activationPhosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowthCyclin-dependent kinase inhibitors and JNK act as molecular switches, regulating the choice between growth arrest and apoptosis induced by galectin-8MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinaseIdentification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinasesDifferential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2Cooperation of phosphoinositides and BAR domain proteins in endosomal tubulationInteraction of the Grb10 adapter protein with the Raf1 and MEK1 kinasesInduction of cyclooxygenase-2 by the activated MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathwayActivation of two isoforms of mitogen-activated protein kinase kinase in response to epidermal growth factor and nerve growth factorInteraction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activationInduction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathwayIonizing radiation stimulates a Grb2-mediated association of the stress-activated protein kinase with phosphatidylinositol 3-kinase
P2860
Q22008673-788B0C34-6B38-4F2C-90C1-9E23D09E7386Q22009135-466CD93F-9FEC-4476-A014-0E770A517ABFQ22010783-DB9C89A9-A9F8-4935-9D8C-F8D32731914AQ24294660-588AB5D2-EF7A-446A-A08C-E19632DB2B31Q24315036-A06B089A-F868-447F-847E-D32E7C07EA4BQ24319291-26DCBDD3-A1C9-4AEE-A38F-C0F0E01C8CDAQ24320233-62DD4329-2DF2-408B-96BE-9961A453DFE6Q24321754-BE7E0E5D-B7C1-423B-A017-61C8B9CCC349Q24321919-5D628A45-D3DE-4096-8BF9-0739941197A2Q24322707-92BB9F56-1481-480A-BF6F-7A70E3B0640CQ24323024-539F79BC-0482-40D3-90E7-B8A1060E79F1Q24323097-0FFF4C96-688F-44AD-A9C2-32CA0025C333Q24336501-39788254-A92C-4743-A595-B96CA7486116Q24336966-1142CD6F-5087-4809-B7BD-573D26BA4E99Q24600810-850C4B95-B9E8-47B7-848F-0225C249FEAAQ24648132-6442DB3F-3B18-42DE-BCD2-12C1200E4438Q24650909-1565189B-3097-473A-9FA5-F1FC49FF7582Q24655723-DF55A2D5-F8AD-43EB-AC99-0F865A146987Q27664652-ECF43EDA-D2C9-4430-AA10-2B6141C33270Q28141738-B7C072EE-B2BC-48EC-B9A4-D67F4E13E20CQ28143305-FD741983-D45E-4B21-AE66-5FD456BBA279Q28143924-B5D284AA-F9C8-4AB9-9E0A-AAA78112A651Q28145951-659DF953-B70F-4633-8E11-EB28C4375866Q28177171-D4685CBD-8DF5-46A7-BA0C-A0A09D62ACB0Q28189507-2203AA31-FF94-49C6-A24C-C12A71DE2EC1Q28205114-21F8C63D-A861-4806-9E0A-E02C327B61D2Q28206174-8529C690-A2F4-49B3-BA1B-E057008E6B35Q28211693-2FBD1099-E8BA-4CAA-A33C-E7A1797D0E05Q28238607-6CD939B8-23D4-4AA1-AF83-15BE30CF7FACQ28240535-19AAEDD1-1C10-4B3A-9636-BB273882B852Q28249893-9371D20C-F985-45E4-989C-50328289C004Q28257056-7F8EC868-BDCA-4ACE-8340-0F4AE0A01E08Q28265617-0E662474-9B2E-4A11-8931-8321FAFAA427Q28266081-22307FE3-0961-4EA7-9949-E740B6A091B5Q28268392-D885163D-77BE-4AEB-BCD9-F1B4D888A56EQ28270455-F96785D3-E99C-4498-A394-9644B55936C8Q28270919-4499473B-175E-41A2-A81A-42E2F5E5A440Q28277712-32A69159-70A2-4A1B-B3E9-67F868DBD9F0Q28279767-0908A51C-C062-4E98-8ABD-D0E1514F3EB7Q28295568-04AEF828-2012-40EF-8D91-CEB519001DA2
P2860
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
description
article publié dans la revue scientifique Nature
@fr
scientific article published in Nature
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в Nature в грудні 1994
@uk
name
Role of SAPK/ERK kinase-1 in t ...... ing transcription factor c-Jun
@en
Role of SAPK/ERK kinase-1 in t ...... ing transcription factor c-Jun
@nl
type
label
Role of SAPK/ERK kinase-1 in t ...... ing transcription factor c-Jun
@en
Role of SAPK/ERK kinase-1 in t ...... ing transcription factor c-Jun
@nl
prefLabel
Role of SAPK/ERK kinase-1 in t ...... ing transcription factor c-Jun
@en
Role of SAPK/ERK kinase-1 in t ...... ing transcription factor c-Jun
@nl
P2093
P356
P1433
P1476
Role of SAPK/ERK kinase-1 in t ...... ing transcription factor c-Jun
@en
P2093
Bruce J. Mayer
Irma Sánchez
James R. Woodgett
John M. Kyriakls
Joseph Avruch
Leonard I. Zon
Rowland T. Hughes
P2888
P304
P356
10.1038/372794A0
P407
P577
1994-12-01T00:00:00Z
P6179
1012539120