Stress induces AMPK-dependent loss of potency factors Id2 and Cdx2 in early embryos and stem cells [corrected].
about
When stresses collideStress-induced enzyme activation primes murine embryonic stem cells to differentiate toward the first extraembryonic lineageEndoplasmic reticulum stress signaling in mammalian oocytes and embryos: life in balanceDevelopment and Validation of a Rex1-RFP Potency Activity Reporter Assay That Quantifies Stress-Forced Potency Loss in Mouse Embryonic Stem Cells.Departure from optimal O2 level for mouse trophoblast stem cell proliferation and potency leads to most rapid AMPK activation.Commonly used fertility drugs, a diet supplement, and stress force AMPK-dependent block of stemness and development in cultured mammalian embryos.Blastocyst-Derived Stem Cell Populations under Stress: Impact of Nutrition and Metabolism on Stem Cell Potency Loss and Miscarriage.AMPK Knockdown in Placental Labyrinthine Progenitor Cells Results in Restriction of Critical Energy Resources and Terminal Differentiation Failure.AMPK and Placental Progenitor Cells.Using stem cell oxygen physiology to optimize blastocyst culture while minimizing hypoxic stress.Two-cell embryos are more sensitive than blastocysts to AMPK-dependent suppression of anabolism and stemness by commonly used fertility drugs, a diet supplement, and stress.Treatment with AICAR inhibits blastocyst development, trophectoderm differentiation and tight junction formation and function in mice.CoQ10 increases mitochondrial mass and polarization, ATP and Oct4 potency levels, and bovine oocyte MII during IVM while decreasing AMPK activity and oocyte death.AMPK improves gut epithelial differentiation and barrier function via regulating Cdx2 expression.Why AMPK agonists not known to be stressors may surprisingly contribute to miscarriage or hinder IVF/ART.
P2860
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P2860
Stress induces AMPK-dependent loss of potency factors Id2 and Cdx2 in early embryos and stem cells [corrected].
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Stress induces AMPK-dependent ...... os and stem cells [corrected].
@en
type
label
Stress induces AMPK-dependent ...... os and stem cells [corrected].
@en
prefLabel
Stress induces AMPK-dependent ...... os and stem cells [corrected].
@en
P2093
P2860
P356
P1476
Stress induces AMPK-dependent ...... os and stem cells [corrected].
@en
P2093
Awoniyi Awonuga
Daniel A Rappolee
Edmond Rings
Elizabeth Ella Puscheck
P2860
P304
P356
10.1089/SCD.2012.0352
P577
2013-03-11T00:00:00Z