Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. - Wikidata - awgldk - TriplyDB

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.

http://www.wikidata.org/entity/Q36843504

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Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancer Cep76, a centrosomal protein that specifically restrains centriole reduplication Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression Genomic screening with RNAi: results and challenges KIFC1: a promising chemotherapy target for cancer treatment?Oocyte Maturation and Development Myosin-X and disease Centrosomes, chromosome instability (CIN) and aneuploidy Myosins in cell junctions And the dead shall rise: actin and myosin return to the spindle Increased asymmetric and multi-daughter cell division in mechanically confined microenvironments Mechanical stress impairs mitosis progression in multi-cellular tumor spheroids Excess centrosomes perturb dynamic endothelial cell repolarization during blood vessel formation.The Msd1-Wdr8-Pkl1 complex anchors microtubule minus ends to fission yeast spindle pole bodies.Direct Microtubule-Binding by Myosin-10 Orients Centrosomes toward Retraction Fibers and Subcortical Actin Clouds.Aneuploidy causes premature differentiation of neural and intestinal stem cells Clustered Intracellular Salmonella enterica Serovar Typhimurium Blocks Host Cell Cytokinesis.A CEP215-HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110 Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function Minus-end-directed Kinesin-14 motors align antiparallel microtubules to control metaphase spindle length The more the messier: centrosome amplification as a novel biomarker for personalized treatment of colorectal cancers Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapy Drugging the addict: non-oncogene addiction as a target for cancer therapy CDK5RAP2 regulates centriole engagement and cohesion in mice A mechanism linking extra centrosomes to chromosomal instability The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation.Germ Cell-less Promotes Centrosome Segregation to Induce Germ Cell Formation.Kif2a depletion generates chromosome segregation and pole coalescence defects in animal caps and inhibits gastrulation of the Xenopus embryo.Merlin/ERM proteins establish cortical asymmetry and centrosome position.Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos.Proper organization of microtubule minus ends is needed for midzone stability and cytokinesis.The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression Cut homeobox 1 causes chromosomal instability by promoting bipolar division after cytokinesis failure.A novel microtubule-modulating noscapinoid triggers apoptosis by inducing spindle multipolarity via centrosome amplification and declustering.Myosin-X functions in polarized epithelial cells.The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells.Cell trivision of hyperploid cells

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P2860

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.

http://www.wikidata.org/entity/Q36843504

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

@zh-cn

name

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.

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type

label

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.

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prefLabel

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.

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Genes & Development

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Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.

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Ammar Azioune

http://www.w3.org/2001/XMLSchema#string

David Pellman

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Manuel Thery

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Mijung Kwon

http://www.w3.org/2001/XMLSchema#string

Namrata S Chandhok

http://www.w3.org/2001/XMLSchema#string

Neil J Ganem

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Susana A Godinho

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P2860

N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis.

Genes required for mitotic spindle assembly in Drosophila S2 cells

Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets

A functional genomic analysis of cell morphology using RNA interference

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

Targeted cancer therapies based on the inhibition of DNA strand break repair

Comparative study and improvement of current cell micro-patterning techniques

Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation

Experimental and theoretical study of mitotic spindle orientation

Oncogenic pathway signatures in human cancers as a guide to targeted therapies

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2189-2203

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10.1101/GAD.1700908

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16

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22

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18662975

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2518815

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