Three amino acid substitutions selectively disrupt the activation but not the repression function of the glucocorticoid receptor N terminus.
about
A tissue-specific coactivator of steroid receptors, identified in a functional genetic screenThe PGC-1-related protein PERC is a selective coactivator of estrogen receptor alphaRecruitment of the SWI-SNF chromatin remodeling complex as a mechanism of gene activation by the glucocorticoid receptor tau1 activation domain.Structure and function of steroid receptor AF1 transactivation domains: induction of active conformationsFar3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiaeThe glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domainThe p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficaciesA genetic analysis of glucocorticoid receptor signaling. Identification and characterization of ligand-effect modulators in Saccharomyces cerevisiae.A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3A point mutation of the AF2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid receptor coactivator 1MNAR functionally interacts with both NH2- and COOH-terminal GR domains to modulate transactivationTranscriptional coactivation of bone-specific transcription factor Cbfa1 by TAZSmall ubiquitin-like modifier (SUMO) modification of the androgen receptor attenuates polyglutamine-mediated aggregationA sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface.Drugs mediate the transcriptional activation of the 5-aminolevulinic acid synthase (ALAS1) gene via the chicken xenobiotic-sensing nuclear receptor (CXR).A role for the Hsp40 Ydj1 in repression of basal steroid receptor activity in yeastGenetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter.Hormone binding and co-regulator binding to the glucocorticoid receptor are allosterically coupled.Building transcriptional regulatory complexes: signals and surfaces.Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor.Activation of nuclear receptor coactivator PGC-1alpha by arginine methylationRegulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor.Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoidsHistone acetyltransferase complexes can mediate transcriptional activation by the major glucocorticoid receptor activation domainTBP binding-induced folding of the glucocorticoid receptor AF1 domain facilitates its interaction with steroid receptor coactivator-1GPR50 interacts with TIP60 to modulate glucocorticoid receptor signalling.Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones.Serum cholesterol selectively regulates glucocorticoid sensitivity through activation of JNKAlternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts.Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity.Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor.Direct and distinguishable inhibitory roles for SUMO isoforms in the control of transcriptional synergy.Regulation of expanded polyglutamine protein aggregation and nuclear localization by the glucocorticoid receptor.Crosstalk pathway for inhibition of glucocorticoid-induced apoptosis by T cell receptor signaling.Unliganded and hormone-bound glucocorticoid receptors interact with distinct hydrophobic sites in the Hsp90 C-terminal domain.Glucocorticoids repress NF-kappaB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cellThe ligand binding domain controls glucocorticoid receptor dynamics independent of ligand release.Small ubiquitin-like modifier (SUMO) modification mediates function of the inhibitory domains of developmental regulators FOXC1 and FOXC2Comparative genomics reveals functional transcriptional control sequences in the Prop1 gene.The in vivo role of androgen receptor SUMOylation as revealed by androgen insensitivity syndrome and prostate cancer mutations targeting the proline/glycine residues of synergy control motifs.
P2860
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P2860
Three amino acid substitutions selectively disrupt the activation but not the repression function of the glucocorticoid receptor N terminus.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Three amino acid substitutions ...... corticoid receptor N terminus.
@en
type
label
Three amino acid substitutions ...... corticoid receptor N terminus.
@en
prefLabel
Three amino acid substitutions ...... corticoid receptor N terminus.
@en
P2860
P356
P1476
Three amino acid substitutions ...... ocorticoid receptor N terminus
@en
P2093
P2860
P304
P356
10.1074/JBC.272.7.4149
P407
P577
1997-02-01T00:00:00Z