Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology.
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Development of oral agent in the treatment of multiple sclerosis: how the first available oral therapy, Fingolimod will change therapeutic paradigm approachNew insights into sodium transport regulation in the distal nephron: Role of G-protein coupled receptorsPonesimod, a selective S1P1 receptor modulator: a potential treatment for multiple sclerosis and other immune-mediated diseasesThe human plasma lipidomeSemaphorins and neuropilins: new players in the neuroendocrine control of the intrathymic T-cell migration in humansBenefits versus risks of latest therapies in multiple sclerosis: a perspective reviewSphingosine kinase and sphingosine 1-phosphate in the heart: a decade of progressVagomimetic effects of fingolimod: physiology and clinical implicationsFingolimod for the treatment of neurological diseases-state of play and future perspectivesThe Direct Effects of Fingolimod in the Central Nervous System: Implications for Relapsing Multiple SclerosisLysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expressionFTY720 protects cardiac microvessels of diabetes: a critical role of S1P1/3 in diabetic heart diseaseThe clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradycardia (S1P₁) and hypertension (S1P₃) in ratFingolimod phosphate attenuates oligomeric amyloid β-induced neurotoxicity via increased brain-derived neurotrophic factor expression in neuronsSphingosine-1-Phosphate Induces Dose-Dependent Chemotaxis or Fugetaxis of T-ALL Blasts through S1P1 ActivationPathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive AntagonismSphingosine 1-phosphate receptor-1 enhances mitochondrial function and reduces cisplatin-induced tubule injury.Drugging sphingosine kinases.Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate.Characterization of a sphingosine 1-phosphate receptor antagonist prodrugSphingosine 1-phosphate chemical biologyInternational Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature.Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D.Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNSSphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney diseaseBiological roles of lysophospholipid receptors revealed by genetic null mice: an update.Promigratory and procontractile growth factor environments differentially regulate cell morphogenesisTwo-photon microscopy analysis of leukocyte trafficking and motility.Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1)Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P1 and S1P5.The differential effects of FTY720 on functional recovery and infarct size following myocardial ischaemia/reperfusion.Sphingosine kinase and sphingosine 1-phosphate in cardioprotection.Cardiomyocyte S1P1 receptor-mediated extracellular signal-related kinase signaling and desensitizationHigh-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia-reoxygenation through lipoprotein-associated sphingosine 1-phosphate.A sphingosine-1-phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigrationMechanism of action of oral fingolimod (FTY720) in multiple sclerosis.Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis.The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin
P2860
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P2860
Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Sphingosine 1-phosphate recept ...... dies and reverse pharmacology.
@en
type
label
Sphingosine 1-phosphate recept ...... dies and reverse pharmacology.
@en
prefLabel
Sphingosine 1-phosphate recept ...... dies and reverse pharmacology.
@en
P1476
Sphingosine 1-phosphate recept ...... dies and reverse pharmacology.
@en
P2093
Volker Brinkmann
P304
P356
10.1016/J.PHARMTHERA.2007.04.006
P577
2007-05-22T00:00:00Z