Molecular and cellular function of ALS2/alsin: implication of membrane dynamics in neuronal development and degeneration.
about
Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseasesDifferent human copper-zinc superoxide dismutase mutants, SOD1G93A and SOD1H46R, exert distinct harmful effects on gross phenotype in miceDefective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formationRho family GTPases: key players in neuronal development, neuronal survival, and neurodegenerationA Toxoplasma MORN1 null mutant undergoes repeated divisions but is defective in basal assembly, apicoplast division and cytokinesisLoss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal traffickingA two-hybrid screen identifies an unconventional role for the intermediate filament peripherin in regulating the subcellular distribution of the SNAP25-interacting protein, SIP30Localized regulation of axonal RanGTPase controls retrograde injury signaling in peripheral nerve.Network inference algorithms elucidate Nrf2 regulation of mouse lung oxidative stressGenome-wide identification of genes probably relevant to the adaptation of schizothoracins (Teleostei: Cypriniformes) to the uplift of the Qinghai-Tibet Plateau.Redox modifier genes and pathways in amyotrophic lateral sclerosis.Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS).DNA repair deficiency in neurodegeneration.Alsin and SOD1(G93A) proteins regulate endosomal reactive oxygen species production by glial cells and proinflammatory pathways responsible for neurotoxicityStrategic approaches to developing drug treatments for ALS.Mitochondrial DNA damage and repair in neurodegenerative disorders.Mutations in the PLEKHG5 gene is relevant with autosomal recessive intermediate Charcot-Marie-Tooth disease.Cellular pathways of hereditary spastic paraplegia.Autophagy and Its Comprehensive Impact on ALS.Is membrane homeostasis the missing link between inflammation and neurodegenerative diseases?Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms.Age-dependent deterioration of locomotion in Drosophila melanogaster deficient in the homologue of amyotrophic lateral sclerosis 2.The transcriptomic response of the coral Acropora digitifera to a competent Symbiodinium strain: the symbiosome as an arrested early phagosome.Endothelial nitric oxide synthase overexpression by neuronal cells in neurodegeneration: a link between inflammation and neuroprotection.Randomized CRISPR-Cas Transcriptional Perturbation Screening Reveals Protective Genes against Alpha-Synuclein Toxicity.Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice.Autophagy as a common pathway in amyotrophic lateral sclerosis.Maternal uniparental heterodisomy with partial isodisomy of a chromosome 2 carrying a splice acceptor site mutation (IVS9-2A>T) in ALS2 causes infantile-onset ascending spastic paralysis (IAHSP).
P2860
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P2860
Molecular and cellular function of ALS2/alsin: implication of membrane dynamics in neuronal development and degeneration.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Molecular and cellular functio ...... development and degeneration.
@en
type
label
Molecular and cellular functio ...... development and degeneration.
@en
prefLabel
Molecular and cellular functio ...... development and degeneration.
@en
P2093
P1476
Molecular and cellular functio ...... l development and degeneration
@en
P2093
Joh-E Ikeda
Kyoko Suzuki-Utsunomiya
Ryota Kunita
Shinji Hadano
P356
10.1016/J.NEUINT.2007.04.010
P50
P577
2007-05-04T00:00:00Z