Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff.
about
E1B 55-kilodalton-associated protein: a cellular protein with RNA-binding activity implicated in nucleocytoplasmic transport of adenovirus and cellular mRNAsAnalysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery.Deletion of the E4 region of the genome produces adenovirus DNA concatemersTransduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesisGoing viral: a review of replication-selective oncolytic adenovirusesAn adenovirus type 5 (Ad5) amplicon-based packaging cell line for production of high-capacity helper-independent deltaE1-E2-E3-E4 Ad5 vectors.Localization and importance of the adenovirus E4orf4 protein during lytic infectionThe adenovirus E1B 55 kd protein influences mRNA transport via an intranuclear effect on RNA metabolismAnalysis of synthesis, stability, phosphorylation, and interacting polypeptides of the 34-kilodalton product of open reading frame 6 of the early region 4 protein of human adenovirus type 5Transforming potential of the adenovirus type 5 E4orf3 protein.Roles for the E4 orf6, orf3, and E1B 55-kilodalton proteins in cell cycle-independent adenovirus replication.Relocalization of the Mre11-Rad50-Nbs1 complex by the adenovirus E4 ORF3 protein is required for viral replicationThe tripartite leader sequence of subgroup C adenovirus major late mRNAs can increase the efficiency of mRNA export.The adenovirus E4-6/7 protein directs nuclear localization of E2F-4 via an arginine-rich motif.The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis.p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection.Recombinant, replication-defective adenovirus gene transfer vectors induce cell cycle dysregulation and inappropriate expression of cyclin proteins.Adenovirus inhibition of cellular protein synthesis is prevented by the drug 2-aminopurine.Induction of the cellular E2F-1 promoter by the adenovirus E4-6/7 protein.The E4-6/7 protein functionally compensates for the loss of E1A expression in adenovirus infectionAdenovirus late gene expression does not require a Rev-like nuclear RNA export pathway.An arginine-faced amphipathic alpha helix is required for adenovirus type 5 e4orf6 protein functionp53-Independent and -dependent requirements for E1B-55K in adenovirus type 5 replication.Induction of transformation and p53-dependent apoptosis by adenovirus type 5 E4orf6/7 cDNA.Identification of three functions of the adenovirus e4orf6 protein that mediate p53 degradation by the E4orf6-E1B55K complexNuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence.Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.Adenovirus early region 4 stimulates mRNA accumulation via 5' introns.Functional analysis of the adenovirus type 5 DNA-binding protein: site-directed mutants which are defective for adeno-associated virus helper activity.Adenovirus VAI RNA complexes with the 68 000 Mr protein kinase to regulate its autophosphorylation and activityRole of adenovirus type 2 early region 4 in the early-to-late switch during productive infection.ONYX-015: mechanisms of action and clinical potential of a replication-selective adenovirus.E4orf6 variants with separate abilities to augment adenovirus replication and direct nuclear localization of the E1B 55-kilodalton protein.The human adenovirus type 5 E1B 55 kDa protein obstructs inhibition of viral replication by type I interferon in normal human cells.Recombinant adenoviral vectors can induce expression of p73 via the E4-orf6/7 proteinA ubiquitin-specific protease possesses a decisive role for adenovirus replication and oncogene-mediated transformation.Distinct roles of the Adenovirus E4 ORF3 protein in viral DNA replication and inhibition of genome concatenation.Insight into the mechanism of inhibition of adeno-associated virus by the Mre11/Rad50/Nbs1 complexEffects of adeno-associated virus on adenovirus replication and gene expression during coinfectionAn activity associated with human chromosome 21 permits nuclear colocalization of the adenovirus E1B-55K and E4orf6 proteins and promotes viral late gene expression.
P2860
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P2860
Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff.
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年論文
@yue
1985年論文
@zh-hant
1985年論文
@zh-hk
1985年論文
@zh-mo
1985年論文
@zh-tw
1985年论文
@wuu
1985年论文
@zh
1985年论文
@zh-cn
name
Adenovirus early region 4 enco ...... ession, and host cell shutoff.
@en
type
label
Adenovirus early region 4 enco ...... ession, and host cell shutoff.
@en
prefLabel
Adenovirus early region 4 enco ...... ession, and host cell shutoff.
@en
P2093
P2860
P1433
P1476
Adenovirus early region 4 enco ...... ession, and host cell shutoff.
@en
P2093
P2860
P304
P407
P577
1985-10-01T00:00:00Z