ONYX-015: mechanisms of action and clinical potential of a replication-selective adenovirus.
about
Gene Therapy Applications to Cancer TreatmentEnhanced therapeutic efficacy by simultaneously targeting two genetic defects in tumors.Antitumor activity of an hTERT promoter-regulated tumor-selective oncolytic adenovirus in human hepatocellular carcinomaIndole-3-carbinol (I3C) increases apoptosis, represses growth of cancer cells, and enhances adenovirus-mediated oncolysisIntact microtubules support adenovirus and herpes simplex virus infections.A novel anticancer therapy that simultaneously targets aberrant p53 and Notch activities in tumorsRecombinant adenoviral vectors can induce expression of p73 via the E4-orf6/7 proteinAn attenuated adenovirus, ONYX-015, as mouthwash therapy for premalignant oral dysplasia.Recent developments and current status of gene therapy using viral vectors in the United Kingdom.Individualised cancer therapeutics: dream or reality? Therapeutics construction.Viruses - seeking and destroying the tumor program.Targeted therapies in the management of metastatic bladder cancerOncolytic-adenovirus-expressed RNA interference for cancer therapy.p53-targeted cancer pharmacotherapy: move towards small molecule compounds.Oncolytic viruses in the treatment of cancer: a review of current strategies.Adenovirus exploits the cellular aggresome response to accelerate inactivation of the MRN complex.E1A, E1B double-restricted replicative adenovirus at low dose greatly augments tumor-specific suicide gene therapy for gallbladder cancer.Inhibition of renal cancer cell growth in vitro and in vivo with oncolytic adenovirus armed short hairpin RNA targeting Ki-67 encoding mRNA.Adenovirus E1B55K region is required to enhance cyclin E expression for efficient viral DNA replication.Elucidation of the molecular mechanism underlying tumor-selective replication of the oncolytic adenovirus mutant ONYX-015.Selective replication of E1B55K-deleted adenoviruses depends on enhanced E1A expression in cancer cells.Model-driven approaches for in vitro combination therapy using ONYX-015 replicating oncolytic adenovirus.
P2860
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P2860
ONYX-015: mechanisms of action and clinical potential of a replication-selective adenovirus.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
ONYX-015: mechanisms of action ...... lication-selective adenovirus.
@ast
ONYX-015: mechanisms of action ...... lication-selective adenovirus.
@en
ONYX-015: mechanisms of action ...... lication-selective adenovirus.
@nl
type
label
ONYX-015: mechanisms of action ...... lication-selective adenovirus.
@ast
ONYX-015: mechanisms of action ...... lication-selective adenovirus.
@en
ONYX-015: mechanisms of action ...... lication-selective adenovirus.
@nl
prefLabel
ONYX-015: mechanisms of action ...... lication-selective adenovirus.
@ast
ONYX-015: mechanisms of action ...... lication-selective adenovirus.
@en
ONYX-015: mechanisms of action ...... lication-selective adenovirus.
@nl
P2860
P921
P356
P1476
ONYX-015: mechanisms of action ...... lication-selective adenovirus.
@en
P2860
P2888
P356
10.1038/SJ.BJC.6600006
P407
P577
2002-01-01T00:00:00Z
2002-01-07T00:00:00Z
P5875
P6179
1004700626