Telomerase reverse transcriptase is required for the localization of telomerase RNA to cajal bodies and telomeres in human cancer cells.
about
HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitmentSpecificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivoTIN2-tethered TPP1 recruits human telomerase to telomeres in vivoTelomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cellsThe Cajal body and histone locus bodyCajal-body formation correlates with differential coilin phosphorylation in primary and transformed cell linesATM and ATR Signaling Regulate the Recruitment of Human Telomerase to TelomeresHuman telomerase: biogenesis, trafficking, recruitment, and activation.Telomere Biology-Insights into an Intriguing Phenomenon.Telomerase trafficking and assembly in Xenopus oocytes.Telomerase Cajal body protein 1 depletion inhibits telomerase trafficking to telomeres and induces G1 cell cycle arrest in A549 cells.Biogenesis and function of nuclear bodies.The role of nuclear bodies in gene expression and disease.A Cajal body-independent pathway for telomerase trafficking in mice.Whole-genome screening identifies proteins localized to distinct nuclear bodiesDisruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita.Human cells lacking coilin and Cajal bodies are proficient in telomerase assembly, trafficking and telomere maintenance.Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly?Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolutionThe Insertion in Fingers Domain in Human Telomerase Can Mediate Enzyme Processivity and Telomerase Recruitment to Telomeres in a TPP1-Dependent Manner.Telomeric G-quadruplexes are a substrate and site of localization for human telomeraseMultiple Mechanisms Contribute to the Cell Growth Defects Imparted by Human Telomerase Insertion in Fingers Domain Mutations Associated with Premature Aging Diseases.Dynamics of Human Telomerase Holoenzyme Assembly and Subunit Exchange across the Cell Cycle.Biogenesis of telomerase ribonucleoproteinsInvolvement of SRSF11 in cell cycle-specific recruitment of telomerase to telomeres at nuclear specklesA translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization.Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts.Human telomerase activity regulation.Structure-function relationship and biogenesis regulation of the human telomerase holoenzyme.TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome endsCatalytically active telomerase holoenzyme is assembled in the dense fibrillar component of the nucleolus during S phase.In-situ hybridization-based quantification of hTR: a possible biomarker in malignant melanoma.Multiscale in situ analysis of the role of dyskerin in lung cancer cells.Telomerase inhibition strategies by siRNAs against either hTR or hTERT in oral squamous cell carcinoma.The regulation of telomerase in oncogenesis.Telomerase RNA Imaging in Budding Yeast and Human Cells by Fluorescent In Situ Hybridization.Tandem affinity purification of AtTERT reveals putative interaction partners of plant telomerase in vivo.Visualization of Human Telomerase Localization by Fluorescence Microscopy Techniques.
P2860
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P2860
Telomerase reverse transcriptase is required for the localization of telomerase RNA to cajal bodies and telomeres in human cancer cells.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Telomerase reverse transcripta ...... lomeres in human cancer cells.
@en
type
label
Telomerase reverse transcripta ...... lomeres in human cancer cells.
@en
prefLabel
Telomerase reverse transcripta ...... lomeres in human cancer cells.
@en
P2093
P2860
P356
P1476
Telomerase reverse transcripta ...... lomeres in human cancer cells.
@en
P2093
Christopher M Counter
Eladio B Abreu
Michael P Terns
Rebecca L Tomlinson
Rebecca M Terns
Tania Ziegler
P2860
P304
P356
10.1091/MBC.E08-02-0184
P577
2008-06-18T00:00:00Z